Abstract
Magnetosomes are nanoparticles coated with organic membrane produced by magnetotactic bacteria. They appear to be a suitable carrier for the targeted drug transport, which represents a new method of cancer treatment. Advantages of targeted drugs transport are the minimizing of hurt to the organism, specific focusing on certain types of tissues, increased effect of the drug, reduced drug dose and hence side effects. The main goal of the present study was to verify the effect of bacterial magnetic nanoparticles produced by Magnetospirillum strain AMB-1 on cancer cell proliferation, plasmatic membrane integrity, induction of apoptosis as well as on the expression of Bcl-2 in the human lung cancer cell line A549. Obtained results showed that magnetosomes did not have a significant effect on proliferation activity of cells but affected their viability. Moreover, they affected structural integrity of plasmatic membrane and induced apoptosis in cancer cells after their incorporation. The expression of Bcl-2 was also significantly reduced. Taking all these data together, it can be emphasized that magnetosomes severely induce apoptosis in lung cancer cells and after performing the further experiments they could be used in different biomedical applications.
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Varchulova Novakova, Z., Gasparova, I., Krajciova, L. et al. Effect of magnetosomes on cell proliferation, apoptosis induction and expression of Bcl-2 in the human lung cancer cell line A549. Biologia 72, 554–560 (2017). https://doi.org/10.1515/biolog-2017-0059
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DOI: https://doi.org/10.1515/biolog-2017-0059