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Malondialdehyde; Lipid peroxidation plasma biomarker correlated with hepatic fibrosis in human Schistosoma mansoni infection

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Abstract

Schistosomiasis is a debilitating parasitic disease, affects large number of host species. Currently affects 250–300 million people in tropic areas. Schistosoma pathogenic impact is hepatic periportal fibrosis; the parasite-induced inflammatory cellular activation promotes oxidative stress, resulting in lipid peroxidation (LPO), with subsequent increase in inflammatory mediators as malondialdehyde (MDA). This study was set up to reveal possible contribution of lipid peroxidation byproducts MDA in hepatic pathophysiology. Results displayed that MDA don’t tend to change in relation with either age, nor hepatic transaminases AST & ALT, while exhibited a significant increase in MDA levels in human schistosomiasis versus control group P<0.0001 (Mn. ± St.dev. 7.77 ± 3.59, 1.21 ± 0.28 nmol/ml) respectively. Moreover; MDA plasma levels in Schistosoma infected group correlated significantly with two hepatic fibrosis parameters; (a) ultrasonography graded periportal fibrosis P< 0.0001. Levels of MDA in hepatic fibrosis grades 0, I, II, III in Schistosoma infected group were (Mn. ± St.dev. 2.8 ± 0.64, 4.3 ± 1.2, 9.3 ± 1.6 and 10.8 ± 1.3 nmol/ml) respectively, (b) serum Hyaluronic acid (HA) P<0.0001 (spearman r = 0.77) as a reliable hepatic fibrosis marker. This implies a considerable role of LPO byproducts in schistosomiasis pathogenicity, and proposing malondi-aldehyde as a biomarker for schistosomiasis morbidity.

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Authors and Affiliations

  1. Department Medical Parasitology, Faculty of Medicine, Cairo University Hospitals, Cairo University Kasr AlAiny street, Kasr AlAiny School of Medicine, Cairo, 11562, Egypt

    Inas Abdel Aziz

  2. Department Clinical & Chemical Pathology, Faculty of Medicine, Cairo University Hospitals, Cairo University Kasr AlAiny street, Kasr AlAiny School of Medicine, Cairo, 11562, Egypt

    Mariam Yacoub

  3. Department Tropical Medicine, Faculty of Medicine, Cairo University Hospitals, Cairo University Kasr AlAiny street, Kasr AlAiny School of Medicine, Cairo, 11562, Egypt

    Laila Rashid

  4. Department Medical Biochemistry, Faculty of Medicine, Cairo University Hospitals, Cairo University Kasr AlAiny street, Kasr AlAiny School of Medicine, Cairo, 11562, Egypt

    Ahmad Solieman

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  1. Inas Abdel Aziz
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  2. Mariam Yacoub
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Correspondence to Inas Abdel Aziz.

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Abdel Aziz, I., Yacoub, M., Rashid, L. et al. Malondialdehyde; Lipid peroxidation plasma biomarker correlated with hepatic fibrosis in human Schistosoma mansoni infection. Acta Parasit. 60, 735–742 (2015). https://doi.org/10.1515/ap-2015-0105

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