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Acta Parasitologica

, Volume 60, Issue 4, pp 735–742 | Cite as

Malondialdehyde; Lipid peroxidation plasma biomarker correlated with hepatic fibrosis in human Schistosoma mansoni infection

  • Inas Abdel AzizEmail author
  • Mariam Yacoub
  • Laila Rashid
  • Ahmad Solieman
Article

Abstract

Schistosomiasis is a debilitating parasitic disease, affects large number of host species. Currently affects 250–300 million people in tropic areas. Schistosoma pathogenic impact is hepatic periportal fibrosis; the parasite-induced inflammatory cellular activation promotes oxidative stress, resulting in lipid peroxidation (LPO), with subsequent increase in inflammatory mediators as malondialdehyde (MDA). This study was set up to reveal possible contribution of lipid peroxidation byproducts MDA in hepatic pathophysiology. Results displayed that MDA don’t tend to change in relation with either age, nor hepatic transaminases AST & ALT, while exhibited a significant increase in MDA levels in human schistosomiasis versus control group P<0.0001 (Mn. ± St.dev. 7.77 ± 3.59, 1.21 ± 0.28 nmol/ml) respectively. Moreover; MDA plasma levels in Schistosoma infected group correlated significantly with two hepatic fibrosis parameters; (a) ultrasonography graded periportal fibrosis P< 0.0001. Levels of MDA in hepatic fibrosis grades 0, I, II, III in Schistosoma infected group were (Mn. ± St.dev. 2.8 ± 0.64, 4.3 ± 1.2, 9.3 ± 1.6 and 10.8 ± 1.3 nmol/ml) respectively, (b) serum Hyaluronic acid (HA) P<0.0001 (spearman r = 0.77) as a reliable hepatic fibrosis marker. This implies a considerable role of LPO byproducts in schistosomiasis pathogenicity, and proposing malondi-aldehyde as a biomarker for schistosomiasis morbidity.

Keywords

Lipid peroxidation Malondialdehyd Schistosoma mansoni Hyaluronic acid 

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Copyright information

© Witold Stefański Institute of Parasitology, Polish Academy of Sciences 2015

Authors and Affiliations

  • Inas Abdel Aziz
    • 1
    Email author
  • Mariam Yacoub
    • 2
  • Laila Rashid
    • 3
  • Ahmad Solieman
    • 4
  1. 1.Department Medical Parasitology, Faculty of MedicineCairo University HospitalsCairoEgypt
  2. 2.Department Clinical & Chemical Pathology, Faculty of MedicineCairo University HospitalsCairoEgypt
  3. 3.Department Tropical Medicine, Faculty of MedicineCairo University HospitalsCairoEgypt
  4. 4.Department Medical Biochemistry, Faculty of MedicineCairo University HospitalsCairoEgypt

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