, Volume 16, Issue 2, pp 115–123 | Cite as

Adverse effects of androgen deprivation therapy in patients with prostate cancer: focus on metabolic complications

  • Vasileios TzortzisEmail author
  • Michael Samarinas
  • Ioannis Zachos
  • Athanasios Oeconomou
  • Louis L. Pisters
  • Alexandra Bargiota


Prostate cancer is the most common cancer among men and androgen deprivation therapy (ADT) is the most effective treatment for this disease. The cornerstone of the treatment of prostate cancer is inhibition of testosterone production which interrupts testosterone-induced growth of the prostate tumor. The dramatic decrease in testosterone levels, however, has several undesirable effects on the metabolic profile and bone metabolism and can also lead to fatigue, loss of libido, gynecomastia, and anemia, provoke vasomotor flushing, and generally affect the quality of life. Due to the long-term survival rates of patients with prostate cancer, treatment-related adverse effects are highly relevant and thus, in each clinical setting, the benefits of ADT must be weighed against treatment-related adverse effects. The current review focuses on the more recently described metabolic complications of androgen deprivation therapy, including obesity, diabetes, lipid alterations, metabolic syndrome, and cardiovascular disease. In addition, it provides practical management recommendations drawn from the available guidelines issued by the American Diabetes Association and American Heart Association.

Key words

Androgen deprivation therapy Diabetes Metabolic complications Prostate cancer 


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Copyright information

© Hellenic Endocrine Society 2017

Authors and Affiliations

  • Vasileios Tzortzis
    • 1
    Email author
  • Michael Samarinas
    • 1
  • Ioannis Zachos
    • 1
  • Athanasios Oeconomou
    • 1
  • Louis L. Pisters
    • 2
  • Alexandra Bargiota
    • 3
  1. 1.Department of Urology, Faculty of Medicine, School of Health SciencesUniversity of ThessalyLarissaGreece
  2. 2.Department of Urology, Division of SurgeryThe University of Texas MD Anderson Cancer CenterHoustonUSA
  3. 3.Department of Endocrinology and Metabolic Diseases, Faculty of Medicine, School of Health SciencesUniversity of ThessalyLarissaGreece

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