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Hormones

, Volume 14, Issue 4, pp 660–667 | Cite as

Sheehan’s syndrome in Xinjiang: Clinical characteristics and laboratory evaluation of 97 patients

  • Guo-li Du
  • Zhong-hua Liu
  • Min Chen
  • Rui Ma
  • Sheng Jiang
  • Miriguli Shayiti
  • Jun Zhu
  • Aibibai Yusufu
Research paper

Abstract

OBJECTIVE: To evaluate the clinical and hormonal characteristics of patients with Sheehan’s syndrome in Xinjiang, China. METHODS: 97 cases diagnosed as Sheehan’s syndrome in our hospital from 1999 to 2013 were retrospectively reviewed. The medical history, physical examination findings and hormonal profiles were documented and analyzed. RESULTS: The mean age at diagnosis was 43.7±12.4 years, with a mean diagnostic delay of 9.1±9.5 years (range, 1 month–35 years). 10 of our patients (10.3%) had a home birth. 96 of our patients (99.0%) had a history of obstetric hemorrhage. The most common clinical presentation included amenorrhea (80/97, 82.5%), agalactia (2/97, 74.2%) and loss of axillary or pubic hair (83/97, 85.6%). Seventy two of our patients (74.2%) failed to lactate and 80 of our patients (82.5%) failed to resume menstruation. Hypothalamic dysfunction included the hypothalamic-pituitary-gonadal axis (HPG) (LH deficiency: 77/83 patients, 92.8%; FSH deficiency: 73/83 patients, 88%; E2 deficiency: 62 of 82 patients,75.6%), the hypothalamic-pituitary-thyroid (HPT) axis (TSH deficiency: 77/93 patients, 82.8%, TT3 deficiency: 70/87 patients, 80.5%, TT4 deficiency: 72/87 patients, 82.8%) and the hypothalamus-pituitary-adrenal (HPA) axis (ACTH deficiency: 19/37 patients, 51.4%, Cortisol deficiency: 49/64, 76.6%). CONCLUSIONS: Sheehan’s syndrome is still common in Xinjiang, especially in rural areas. Long diagnosis delay in most of the patients indicates that women might be lacking correct diagnosis and treatment. Physicians need to be aware of the most important clues for diagnosis such as lack of lactation in the postpartum period and failure to resume menstruation.

Key words

Diagnosis delay Hypopituitarism Postpartum hemorrhage Sheehan’s syndrome 

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Copyright information

© Hellenic Endocrine Society 2015

Authors and Affiliations

  • Guo-li Du
    • 1
  • Zhong-hua Liu
    • 2
  • Min Chen
    • 3
  • Rui Ma
    • 1
  • Sheng Jiang
    • 1
  • Miriguli Shayiti
    • 4
  • Jun Zhu
    • 1
  • Aibibai Yusufu
    • 1
  1. 1.Department of EndocrinologyFirst Affiliated Hospital of Xinjiang Medical UniversityXinjiangChina
  2. 2.Department of Endocrinologythe Eastern Section of Linyi People’s HospitalLinyiChina
  3. 3.Department of Rehabilitation MedicinePeople’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiChina
  4. 4.Department of MRIFirst Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina

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