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Hormones

, Volume 11, Issue 3, pp 356–360 | Cite as

Very premature pubarche in girls is not a pubertal variant

  • Françoise Paris
  • Nicolas Kalfa
  • Pascal Philibert
  • Claire Jeandel
  • Laura Gaspari
  • Charles Sultan
Case report

Abstract

Premature pubarche (PP) in girls is considered to be a benign phenomenon and is the clinical expression of premature adrenarche. Since it does not usually increase the risk of either abnormalities in pubertal development or a reduced final adult height, a non-interventional approach is generally adopted after exclusion of non-classical (NC) congenital adrenal hyper-plasia (CAH). Extremely premature pubarche is nevertheless not a pubertal variant. We here report two cases of adrenocortical tumors (ACT) for which precocious pubarche was the initial sign. This report suggests that premature pubarche is not always a mere pubertal variant and that a delay in the etiological diagnosis can be harmful. Therefore, pubarche before the age of four years should be considered as a feature of ACT or NC CAH until proven otherwise.

Key words

Adrenarche Adrenortical carcinoma Puberty 

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Copyright information

© Hellenic Endocrine Society 2012

Authors and Affiliations

  • Françoise Paris
    • 1
  • Nicolas Kalfa
    • 1
    • 2
    • 3
  • Pascal Philibert
    • 1
    • 2
  • Claire Jeandel
    • 1
    • 2
  • Laura Gaspari
    • 1
    • 2
  • Charles Sultan
    • 1
    • 2
  1. 1.Unité d’Endocrinologie-Gynécologie Pédiatrique, Service de Pédiatrie 1Hôpital Arnaud-de-Villeneuve, CHU MontpellierMontpellierFrance
  2. 2.Departement d’Hormonologie du Développement et de la Reproduction, Hôpital LapeyronieCHU Montpellier, et Université Montpellier 1France
  3. 3.Service de Chirurgie Viscérale et Urologie Pédiatrique, Hôpital LapeyronieCHU Montpellier et Université Montpellier 1France

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