, Volume 9, Issue 1, pp 16–27 | Cite as

Neuroendocrine targets of endocrine disruptors

  • Andrea C. Gore


The central neuroendocrine systems are responsible for the control of homeostatic processes in the body, including reproduction, growth, metabolism and energy balance, as well as stress responsiveness. These processes are initiated by signals in the central nervous system, specifically the hypothalamus, and are conveyed first by neural and then by endocrine effectors. The neuroendocrine systems, as the links between the brain and peripheral endocrine organs, play critical roles in the ability of an organism to respond to its environment under normal circumstances. When neuroendocrine homeostasis is disrupted by environmental endocrine-disrupting chemicals, a variety of perturbations can ensue, particularly when endocrine disruption occurs during critical developmental time periods. This article will discuss the evidence for environmental endocrine disruption of neuroendocrine systems and the effects on endocrine and reproductive functions.


Endocrine disruption Epigenetic Fetal basis of adult disease GnRH Hypothalamus Sex differences Thyroid Transgenerational 


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Copyright information

© Hellenic Endocrine Society 2010

Authors and Affiliations

  1. 1.Center for Molecular and Cellular Toxicology, Division of Pharmacology & Toxicology, College of Pharmacy; Institute for Cellular and Molecular Biology; and Institute for NeuroscienceUniversity of TexasAustinUSA

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