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Mediterranean-Dash Intervention for Neurodegenerative Delay (MIND) Diet Slows Cognitive Decline After Stroke



This study sought to determine if the MIND diet (a hybrid of the Mediterranean and Dash diets, with modifications based on the science of nutrition and the brain), is effective in preventing cognitive decline after stroke.


We analyzed 106 participants of a community cohort study who had completed a diet assessment and two or more annual cognitive assessments and who also had a clinical history of stroke. Cognition in five cognitive domains was assessed using structured clinical evaluations that included a battery of 19 cognitive tests. MIND diet scores were computed using a valid food frequency questionnaire (FFQ). Dietary components of the MIND diet included whole grains, leafy greens and other vegetables, berries, beans, nuts, lean meats, fish, poultry, and olive oil and reduced consumption of cheese, butter, fried foods, and sweets. MIND diet scores were modeled in tertiles. The influence of baseline MIND score on change in a global cognitive function measure and in the five cognitive domains was assessed using linear mixed models adjusted for age and other potential confounders.


With adjustment for age, sex, education, APOE-ε4, caloric intake, smoking, and participation in cognitive and physical activities, the top vs lowest tertiles of MIND diet scores had a slower rate of global cognitive decline (β =.08; CI = 0.0074, 0.156) over an average of 5.9 years of follow-up.


High adherence to the MIND diet was associated with a slower rate of cognitive decline after stroke.

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Funding: Supported by grants from the NIA (R01 AG054476 and R01AG17917). The sponsors had no role in the design and conduct of the study; in the collection, analysis, and interpretation of data; in the preparation of the manuscript; or in the review or approval of the manuscript.

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Correspondence to Laurel Cherian.

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Conflict of Interest and Financial Disclosures: Laurel Cherian: Study concept and design, Interpretation of data, and writing of manuscript. Dr. Cherian reports no disclosures. Yamin Wang: Analysis and interpretation. Dr. Wang reports no disclosures. Keiko Fakuda: Background research and initial draft of introduction and discussion. Ms. Fakuda reports no disclosures. Sue Leurgans: Critical revision of the manuscript for important intellectual content. Dr. Leurgans reports no disclosures. Neelum Aggarwal: Study concept and design, critical revision of the manuscript for important intellectual content. Dr. Aggarwal reports no disclosures. Martha Clare Morris: Study concept and design, critical revision of the manuscript for important intellectual content. Dr. Morris reports no disclosures.

Ethical standards: The authors attest that they have provided an accurate account of the work performed as well as an objective discussion of its significance. Relevant raw data has been accurately provided. The authors attest that the work is original and has not been published elsewhere. Pertinent work from other sources has been appropriately cited. The Institutional Review Board of Rush University Medical Center approved the study, and all participants gave written informed consent.

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Cherian, L., Wang, Y., Fakuda, K. et al. Mediterranean-Dash Intervention for Neurodegenerative Delay (MIND) Diet Slows Cognitive Decline After Stroke. J Prev Alzheimers Dis 6, 267–273 (2019).

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Key words

  • Stroke
  • cognitive decline
  • diet
  • nutrition
  • prevention