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Bifidobacterium Breve A1 Supplementation Improved Cognitive Decline in Older Adults with Mild Cognitive Impairment: An Open-Label, Single-Arm Study

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Abstract

Objectives

We previously reported the therapeutic potential of Bifidobacterium breve A1 (B. breve A1) for preventing cognitive impairment in Alzheimer’s disease model mice, which suggested that supplementation of the probiotics could be an effective therapeutic strategy for managing cognitive function in mild cognitive impairment (MCI).

Design and Settings

We conducted an open-label, single-arm study to examine the effects of 24-week supplementation of B. breve A1 on elderly with MCI in Aki Orthopedics Rehabilitation Clinic in Japan.

Participants

27 participants were screened by their Mini Mental State Examination (MMSE) scores.

Measurements

Cognitive function was assessed using MMSE and Digit Symbol Substitution Test (DSST) at baseline and every 8 weeks. Mental condition and quality of life for gastrointestinal symptoms were measured using the Profile of Mood States 2nd Edition (POMS2), and the Gastrointestinal Symptom Rating Scale (GSRS).

Results

Of the 27 participants enrolled, 19 completed the study. MMSE scores were significantly increased during the intervention by mixed model Dunnett’s test and Wilcoxon signed-rank tests (+1.7, P < 0.01). POMS2 and GSRS scores were significantly improved during intervention when analyzed by Wilcoxon signed-rank tests.

Conclusion

The present study showed that oral supplementation of B. breve A1 in participants with MCI improved cognitive function, thus suggesting the potential of B. breve A1 for improving cognitive function and maintaining quality of life of the elderly. Further randomized, double-blind placebo-controlled studies are worth conducting to examine the beneficial effect of B. breve A1.

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Authors and Affiliations

  1. Morinaga Milk Industry Co., Ltd., Next Generation Science Institute, 5-1-83 Higashihara, Zama, Kanagawa, 252-8583, Japan

    Yodai Kobayashi & J.-Z. Xiao

  2. Department of Community Health Systems Nursing, Ehime University Graduate School of Medicine, Toon, Ehime, Japan

    T. Kinoshita & I. Saito

  3. Institute of Community Life Sciences Co., Ltd, Matsuyama, Ehime, Japan

    T. Kinoshita

  4. Aki Orthopedics Rehabilitation Clinic, Matsuyama, Ehime, Japan

    A. Matsumoto & K. Yoshino

Authors
  1. Yodai Kobayashi
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  2. T. Kinoshita
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  3. A. Matsumoto
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  4. K. Yoshino
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  5. I. Saito
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  6. J.-Z. Xiao
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Correspondence to Yodai Kobayashi.

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Kobayashi, Y., Kinoshita, T., Matsumoto, A. et al. Bifidobacterium Breve A1 Supplementation Improved Cognitive Decline in Older Adults with Mild Cognitive Impairment: An Open-Label, Single-Arm Study. J Prev Alzheimers Dis 6, 70–75 (2019). https://doi.org/10.14283/jpad.2018.32

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  • DOI: https://doi.org/10.14283/jpad.2018.32

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