Skip to main content

Advertisement

SpringerLink
Log in

Effect of a 12-Week Mixed Training on Body Quality in People Living with HIV: Does Age and HIV Duration Matter?

  • Clinical Trials and Therapeutics
  • Original Research
  • Published:
The Journal of Frailty & Aging Aims and scope Submit manuscript

Abstract

Background

The impact of HIV duration on exercise adaptations has not yet been studied. Moreover, the age at which subjects living with HIV are the most responsive to exercise is not clear.

AIMS

Investigate the effect of a mixed exercise training program on physical performance changes in individuals living with HIV and explore if age or HIV duration influence these adaptations in men.

Methods

In this feasibility study, participants followed a 12-week mixed exercise training program, three times/week, 45 min/session. Physical performance including functional capacities (normal 4-m walking test, 6min walking test), grip strength (hand dynamometer), muscle power, body composition (android and gynoid fat masses, appendicular lean mass) were evaluated pre- and post-intervention. Subgroup analysis according to the median age of the participants (age<50yrs vs. age≥50yrs) and median HIV duration (HIV<20yrs vs. HIV≥20yrs) were performed in men.

Results

A total of 27 participants (age: 54.5±6.8yrs, men: 85%; HIV duration: 19.3±7.6yrs) were included. At the end of the intervention, significant increases compared to baseline were seen in grip strength (p=0.017), leg power (p<0.001), normal walking speed (p<0.001) and 6-min walking distance (p=0.003). Following the intervention, parameters improved similarly in both age groups. However improvement was greater in those with HIV>20yrs than those with a shorter infection duration, with change (%) on total (p<0.001), android (p=0.02), and gynoid (p=0.05) fat masses as well as appendicular lean mass index (p=0.03).

Conclusion

Mixed exercise training seems to be an effective intervention to improve physical performance in individuals living with HIV. In addition, this study suggests that neither age nor HIV duration has influence on the effect of mixed training in this population.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hawton, A., et al., The impact of social isolation on the health status and health-related quality of life of older people. Qual Life Res, 2011. 20(1): p. 57–67.

    Article  PubMed  Google Scholar 

  2. Bouchard, D.R. and I. Janssen, Dynapenic-obesity and physical function in older adults. J Gerontol A Biol Sci Med Sci, 2010. 65(1): p. 71–7.

    Article  PubMed  Google Scholar 

  3. Rajasuriar, R., et al., Major health impact of accelerated aging in young HIV-infected individuals on antiretroviral therapy. Aids, 2017. 31(10): p. 1393–1403.

    Article  CAS  PubMed  Google Scholar 

  4. Greene, M., et al., Geriatric Syndromes in Older HIV-Infected Adults. J Acquir Immune Defic Syndr, 2015. 69(2): p. 161–7.

    Article  PubMed  PubMed Central  Google Scholar 

  5. McMillan, J.M., et al., An Emerging Concern-High Rates of Frailty among Middle-aged and Older Individuals Living with HIV. Can Geriatr J, 2019. 22(4): p. 190–198.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Guaraldi, G., et al., The Interplay Between Age and Frailty in People Living With HIV: Results From an 11-Year Follow-up Observational Study. Open Forum Infect Dis, 2019. 6(5): p. ofz199.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Desquilbet, L., et al., HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty. J Gerontol A Biol Sci Med Sci, 2007. 62(11): p. 1279–86.

    Article  PubMed  Google Scholar 

  8. Compston, J., HIV infection and osteoporosis. Bonekey Rep, 2015. 4: p. 636.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Mhariwa, P.C., et al., The relationship between lower limb muscle strength and lower extremity function in HIV disease. S Afr J Physiother, 2017. 73(1): p. 360.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Bailin, S.S., et al., Obesity and Weight Gain in Persons with HIV. Curr HIV/AIDS Rep, 2020. 17(2): p. 138–150.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Lake, J.E., The Fat of the Matter: Obesity and Visceral Adiposity in Treated HIV Infection. Curr HIV/AIDS Rep, 2017. 14(6): p. 211–219.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Langhammer, B., A. Bergland, and E. Rydwik, The Importance of Physical Activity Exercise among Older People. Biomed Res Int, 2018. 2018: p. 7856823.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Buckinx, F. and M. Aubertin-Leheudre, Relevance to assess and preserve muscle strength in aging field. Prog Neuropsychopharmacol Biol Psychiatry, 2019: p. 109663.

  14. Voigt, N., H. Cho, and R. Schnall, Supervised Physical Activity and Improved Functional Capacity among Adults Living with HIV: A Systematic Review. J Assoc Nurses AIDS Care, 2018. 29(5): p. 667–680.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Dolan, S.E., et al., Effects of a supervised home-based aerobic and progressive resistance training regimen in women infected with human immunodeficiency virus: a randomized trial. Arch Intern Med, 2006. 166(11): p. 1225–31.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Driscoll, S.D., et al., Effects of exercise training and metformin on body composition and cardiovascular indices in HIV-infected patients. Aids, 2004. 18(3): p. 465–73.

    Article  CAS  PubMed  Google Scholar 

  17. Dudgeon, W.D., et al., Moderate-Intensity Exercise Improves Body Composition and Improves Physiological Markers of Stress in HIV-Infected Men. Isrn aids, 2012. 2012: p. 145127.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Farinatti, P.T., et al., Effects of a supervised exercise program on the physical fitness and immunological function of HIV-infected patients. J Sports Med Phys Fitness, 2010. 50(4): p. 511–8.

    CAS  PubMed  Google Scholar 

  19. Fillipas, S., et al., A six-month, supervised, aerobic and resistance exercise program improves self-efficacy in people with human immunodeficiency virus: a randomised controlled trial. Aust J Physiother, 2006. 52(3): p. 185–90.

    Article  PubMed  Google Scholar 

  20. Ogalha, C., et al., A randomized, clinical trial to evaluate the impact of regular physical activity on the quality of life, body morphology and metabolic parameters of patients with AIDS in Salvador, Brazil. J Acquir Immune Defic Syndr, 2011. 57 Suppl 3: p. S179–85.

    Article  PubMed  Google Scholar 

  21. Pérez-Moreno, F., et al., Benefits of exercise training in Spanish prison inmates. Int J Sports Med, 2007. 28(12): p. 1046–52.

    Article  PubMed  Google Scholar 

  22. Mayo, N.E., M.J. Brouillette, and L.K. Fellows, Understanding and optimizing brain health in HIV now: protocol for a longitudinal cohort study with multiple randomized controlled trials. BMC Neurol, 2016. 16: p. 8.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Eldridge, S.M., et al., CONSORT 2010 statement: extension to randomised pilot and feasibility trials. Pilot Feasibility Stud, 2016. 2: p. 64.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Kaur, N., et al., Feasibility and potential benefits of a structured exercise program on cognitive performance in HIV. AIDS Care, 2021: p. 1–9.

  25. Thomas, S., J. Reading, and R.J. Shephard, Revision of the Physical Activity Readiness Questionnaire (PAR-Q). Can J Sport Sci, 1992. 17(4): p. 338–45.

    CAS  PubMed  Google Scholar 

  26. Buckinx, F., et al., Muscle adaptation in response to a high-intensity interval training in obese older adults: effect of daily protein intake distribution. Aging Clin Exp Res, 2019. 31(6): p. 863–874.

    Article  CAS  PubMed  Google Scholar 

  27. F, B., et al., High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults. Exp Gerontol, 2020. 140: p. 111036.

    Article  CAS  PubMed  Google Scholar 

  28. Baumgartner, R.N., et al., Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol, 1998. 147(8): p. 755–63.

    Article  CAS  PubMed  Google Scholar 

  29. Blew, R.M., et al., Standardizing evaluation of pQCT image quality in the presence of subject movement: qualitative versus quantitative assessment. Calcif Tissue Int, 2014. 94(2): p. 202–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Doube, M., et al., BoneJ: free and extensible bone image analysis in ImageJ. Bone, 2010. 47(6): p. 1076–1079.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Frank-Wilson, A.W., et al., Measurement of muscle and fat in postmenopausal women: precision of previously reported pQCT imaging methods. Bone, 2015. 75: p. 49–54.

    Article  PubMed  Google Scholar 

  32. Clark, B.C. and T.M. Manini, Functional consequences of sarcopenia and dynapenia in the elderly. Curr Opin Clin Nutr Metab Care, 2010. 13(3): p. 271–6.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Tremblay, M.S., et al., Physical activity assessment options within the context of the Canadian Physical Activity, Fitness, and Lifestyle Appraisal. Can J Appl Physiol, 2001. 26(4): p. 388–407.

    Article  CAS  PubMed  Google Scholar 

  34. Hurst, C., et al., Short- and long-term reliability of leg extensor power measurement in middle-aged and older adults. J Sports Sci, 2018. 36(9): p. 970–977.

    Article  PubMed  Google Scholar 

  35. Burr, J.F., et al., The 6-minute walk test as a predictor of objectively measured aerobic fitness in healthy working-aged adults. Phys Sportsmed, 2011. 39(2): p. 133–9.

    Article  PubMed  Google Scholar 

  36. Andersson, M., et al., Measuring walking speed in COPD: test-retest reliability of the 30-metre walk test and comparison with the 6-minute walk test. Prim Care Respir J, 2011. 20(4): p. 434–40.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Wise, R.A. and C.D. Brown, Minimal clinically important differences in the six-minute walk test and the incremental shuttle walking test. Copd, 2005. 2(1): p. 125–9.

    Article  PubMed  Google Scholar 

  38. Cleland, B.T., H. Arshad, and S. Madhavan, Concurrent validity of the GAITRite electronic walkway and the 10-m walk test for measurement of walking speed after stroke. Gait Posture, 2019. 68: p. 458–460.

    Article  PubMed  Google Scholar 

  39. Bonato, M., et al., The Role of Physical Activity for the Management of Sarcopenia in People Living with HIV. Int J Environ Res Public Health, 2020. 17(4).

  40. O’Brien, K.K., et al., Effectiveness of aerobic exercise for adults living with HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol. BMC Infect Dis, 2016. 16: p. 182.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Oursler, K.K., et al., A pilot randomized aerobic exercise trial in older HIV-infected men: Insights into strategies for successful aging with HIV. PLoS One, 2018. 13(6): p. e0198855.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Jankowski, C.M., et al., Body Composition Changes in Response to Moderate- or High-Intensity Exercise Among Older Adults With or Without HIV Infection. J Acquir Immune Defic Syndr, 2020. 85(3): p. 340–345.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Smith, B.A., et al., Aerobic exercise: effects on parameters related to fatigue, dyspnea, weight and body composition in HIV-infected adults. Aids, 2001. 15(6): p. 693–701.

    Article  CAS  PubMed  Google Scholar 

  44. Oursler, K.K., et al., Association of age and comorbidity with physical function in HIV-infected and uninfected patients: results from the Veterans Aging Cohort Study. AIDS Patient Care STDS, 2011. 25(1): p. 13–20.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Gomes-Neto, M., et al., A systematic review of the effects of different types of therapeutic exercise on physiologic and functional measurements in patients with HIV/AIDS. Clinics (Sao Paulo), 2013. 68(8): p. 1157–67.

    Article  Google Scholar 

  46. Grace, J.M., S.J. Semple, and S. Combrink, Exercise therapy for human immunodeficiency virus/AIDS patients: Guidelines for clinical exercise therapists. J Exerc Sci Fit, 2015. 13(1): p. 49–56.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Jaggers, J.R. and G.A. Hand, Health Benefits of Exercise for People Living With HIV: A Review of the Literature. Am J Lifestyle Med, 2016. 10(3): p. 184–192.

    Article  PubMed  Google Scholar 

  48. Wing, E.J., HIV and aging. Int J Infect Dis, 2016. 53: p. 61–68.

    Article  PubMed  Google Scholar 

  49. López-Otín, C., et al., The hallmarks of aging. Cell, 2013. 153(6): p. 1194–217.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Althoff, K.N., et al., Comparison of risk and age at diagnosis of myocardial infarction, end-stage renal disease, and non-AIDS-defining cancer in HIV-infected versus uninfected adults. Clin Infect Dis, 2015. 60(4): p. 627–38.

    Article  PubMed  Google Scholar 

  51. Rasmussen, L.D., et al., Time trends for risk of severe age-related diseases in individuals with and without HIV infection in Denmark: a nationwide population-based cohort study. Lancet HIV, 2015. 2(7): p. e288–98.

    Article  PubMed  Google Scholar 

  52. Ghidei, L., et al., Aging, antiretrovirals, and adherence: a meta analysis of adherence among older HIV-infected individuals. Drugs Aging, 2013. 30(10): p. 809–19.

    Article  PubMed  Google Scholar 

Download references

Funding

Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. FB and MAL are supported by FRQS.

Author information

Authors and Affiliations

  1. Département des Sciences de l’activité physique, Faculté des Sciences, UQAM, Pavillon Sciences Biologiques, SB-4615, 141, Avenue du Président Kennedy, Montréal, Québec, Canada, H2X 1Y4

    F. Buckinx, J. Granet & Mylene Aubertin-Leheudre

  2. Centre de recherche de l’institut Universitaire de Gériatrie de Montréal, Montréal, Canada

    F. Buckinx, J. Granet & Mylene Aubertin-Leheudre

  3. École de réadaptation, Université de Montréal, Montréal, Canada

    A. Bass

  4. School of Physical and Occupational Therapy, McGill University, Montreal, Canada

    N. Kaur & N. Mayo

  5. Division of Clinical Epidemiology, McGill University, Montreal, Canada

    N. Kaur & N. Mayo

  6. Department of Neurology, McGill University, Montreal, Canada

    L. K. Fellows

  7. Department of Psychiatry, McGill University, Montreal, Canada

    M.-J. Brouillette

Authors
  1. F. Buckinx
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Granet
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Bass
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. Kaur
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. K. Fellows
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M.-J. Brouillette
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. N. Mayo
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Mylene Aubertin-Leheudre
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mylene Aubertin-Leheudre.

Additional information

Conflict of Interest: We have no Conflict of Interest.

Informed consent: All participants gave written informed consent.

Ethical Statement details: Full agreement with ethical standards.

Ethical approval: The ethics approval was obtained from the McGill University Health Centre (MUHC) and from the research ethics review committee at the Université du Québec à Montréal (UQAM).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Buckinx, F., Granet, J., Bass, A. et al. Effect of a 12-Week Mixed Training on Body Quality in People Living with HIV: Does Age and HIV Duration Matter?. J Frailty Aging 11, 426–433 (2022). https://doi.org/10.14283/jfa.2022.56

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.14283/jfa.2022.56

Key words

Search

Navigation