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Table 1 Characteristics of patient’s clinical background for generations

From: Clinical Characteristics of Frailty in Japanese Rheumatoid Arthritis Patients

  40s 50s 60s 70s 80s 90s p-value
Cases 58 89 135 260 190 7  
female 33 (56.9%) 74 (83.1%) 102 (75.6%) 211 (81.2%) 159 (84.2%) 7 (100%)  
Stage (I:II:III:IV) 40:7:6:5 55:19:12:3 67:31:22:15 87:77:25:71 52:67:8:70 1:3:1:2 0.96
Class (I:II:III:IV) 24:30:4:0 30:50:6:3 47:72:16:0 51:174:33:2 20:139:35:3 0:5:2:0 <1.00×10−12
Frailty: Pre-frailty: Robust 3:9:46 4: 22: 63 33:16:86 68: 103: 89 103: 54: 33 7:0:0 <1.00×10−12
average of the Frailty score 0.38 0.65 1.19 1.57 2.6 4.86 <1.00×10−12
Frailty category for WL 3 (5.2%) 6 (6.7%) 26 (19.3%) 47 (18.1%) 45 (23.7%) 6 (85.7%) <1.00×10−12
Frailty category for GS 4 (6.9%) 18 (20.2%) 42 (31.1%) 122 (46.9%) 134 (70.5%) 7 (100%) 1.01×10−11
Frailty category for EX 5 (8.6%) 9 (10.1%) 29 (21.5%) 109 (41.9%) 117 (61.6%) 7 (100%) <1.00×10−12
Frailty category for SM 7 (12.1%) 16 (18.0%) 38 (28.1%) 69 (26.5%) 88 (46.3%) 7 (100%) <1.00×10−12
Frailty category for GF 3 (5.2%) 9 (10.1%) 25 (18.5%) 62 (23.8%) 94 (49.5%) 7 (100%) <1.00×10−12
average HAQ-DI score 0.193 0.289 0.372 0.493 0.803 1.681 <1.00×10−12
EQ5D Transfer 1.17, 1–2 1.21, 1–2 1.33, 1–3 1.47, 1–3 1.86, 1–4 2, 1–4 9.84×10−8
EQ5D IADL 1.08, 1–2 1.16, 1–2 1.24, 1–3 1.28, 1–3 1.56, 1–3 2, 1–4 1.85×10−5
EQ5D Activity 1.13, 1–2 1.21, 1–2 1.31, 1–3 1.39, 1–3 1.7, 1–3 2, 1–3 9.50×10−4
EQ5D Pain/Discomfort 1.4, 1–2 1.5, 1–3 1.5, 1–3 1.51, 1–4 1.49, 1–4 2, 1–4 8.00×10−4
EQ5D Anxiety 1.08, 1–2 1.18, 1–2 1.21, 1–3 1.2, 1–3 1.24, 1–3 2, 1–4 0.64
SDAI 6.4, 1.4–31.5 7.3, 0.1–57.4 7.2, 0.1–65.8 5.5, 0.3–35.3 7.8, 0.1–40.3 9.1, 1.7–48.9 3.46×10−07
Number of Comorbidities by organ 2.6 3 3.2 3.6 2.5 1.5 7.47×10−11
Dementia treated 1.7% 3.4% 8.9% 25.0% 54.0% 75.0% 9.36×10−4
  1. Patients with rheumatoid arthritis classified by age in decades: 40s, forties; 50s, fifties; 60s, sixties; 70s, seventies; 80s, eighties; 90s, nineties. Statistical evaluations compared variables among these age groups. The chi-squared test available for M × N was used to assess categorical variables. In other numerical parameters, statistical significance was evaluated with the Kruskal-Wallis test; Abbreviations: S.S., statistical significance; WL, weight loss of 2 to 3 kg in half a year; GS, slower gait speed reported; EX, exercise less than once a week; SM, decline in short-term memory; GF, general fatigue in preceding several weeks; HAQ-DI, Health Assessment Questionnaire Disability Index; EQ5D, EuroQol 5 dimensions; IADL, instrumental activity of daily living; TJC, tenderness joint count; SJC, swollen joint count; PGA, patient’s global assessment; EGA, evaluator’s global assessment; CRP, C-reactive protein; SDAI, Simplified Disease Activity Index; DAS28-CRP, 28-joint Disease Activity Score with CRP. In EQ5D categories and SDAI, mean value and range were shown.
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