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Proceedings of the Canadian Frailty Network Workshop: Identifying Biomarkers of Frailty to Support Frailty Risk Assessment, Diagnosis and Prognosis. Toronto, January 15, 2018

  • John MuscedereEmail author
  • P. M. Kim
  • J. Afilalo
  • C. Balion
  • V. E. Baracos
  • D. Bowdish
  • M. Cesari
  • J. D. Erusalimsky
  • T. Fülöp
  • G. Heckman
  • S. E. Howlett
  • R. G. Khadaroo
  • J. L. Kirkland
  • L. Rodriguez Mañas
  • E. Marzetti
  • G. Paré
  • P. Raina
  • K. Rockwood
  • A. Sinclair
  • C. Skappak
  • C. Verschoor
  • S. Walter
  • Canadian Frailty Network
Special Article

Abstract

The Canadian Frailty Network (CFN), a pan-Canadian not-for-profit organization funded by the Government of Canada through the Networks of Centres of Excellence Program, is dedicated to improving the care of older Canadians living with frailty. The CFN has partnered with the Canadian Longitudinal Study on Aging (CLSA) to measure potential frailty biomarkers in biological samples (whole blood, plasma, urine) collected in over 30,000 CLSA participants. CFN hosted a workshop in Toronto on January 15 2018, bringing together experts in the field of biomarkers, aging and frailty. The overall objectives of the workshop were to start building a consensus on potential frailty biomarker domains and identify specific frailty biomarkers to be measured in the CLSA biological samples. The workshop was structured with presentations in the morning to frame the discussions for the afternoon session, which was organized as a free-flowing discussion to benefit from the expertise of the participants. Participants and speakers were from Canada, Italy, Spain, United Kingdom and the United States. Herein we provide pertinent background information, a summary of all the presentations with key figures and tables, and the distillation of the discussions. In addition, moving forward, the principles CFN will use to approach frailty biomarker research and development are outlined. Findings from the workshop are helping CFN and CLSA plan and conduct the analysis of biomarkers in the CLSA samples and which will inform a follow-up data access competition.

Key words

CFN CLSA frailty frailty index seniors older adults biomarkers aging 

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Copyright information

© Serdi and Springer Nature Switzerland AG 2019

Authors and Affiliations

  • John Muscedere
    • 1
    • 22
    Email author
  • P. M. Kim
    • 2
  • J. Afilalo
    • 3
  • C. Balion
    • 4
  • V. E. Baracos
    • 5
  • D. Bowdish
    • 4
  • M. Cesari
    • 6
    • 7
  • J. D. Erusalimsky
    • 8
  • T. Fülöp
    • 9
  • G. Heckman
    • 10
  • S. E. Howlett
    • 11
  • R. G. Khadaroo
    • 12
  • J. L. Kirkland
    • 13
  • L. Rodriguez Mañas
    • 14
  • E. Marzetti
    • 15
  • G. Paré
    • 4
  • P. Raina
    • 16
  • K. Rockwood
    • 17
  • A. Sinclair
    • 18
  • C. Skappak
    • 19
    • 20
  • C. Verschoor
    • 16
  • S. Walter
    • 21
  • Canadian Frailty Network
  1. 1.Department of Critical Care MedicineQueen’s UniversityKingstonCanada
  2. 2.Canadian Frailty NetworkKingstonCanada
  3. 3.Division of Cardiology and Centre for Clinical Epidemiology, Jewish General HospitalMcGill UniversityMontrealCanada
  4. 4.Department of Pathology and Molecular MedicineMcMaster UniversityHamiltonCanada
  5. 5.Department of OncologyUniversity of AlbertaEdmontonCanada
  6. 6.Department of Clinical Sciences and Community HealthUniversitá di MilanoMilanItaly
  7. 7.Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoMilanItaly
  8. 8.Department of Biomedical SciencesCardiff Metropolitan UniversityCardiffUK
  9. 9.Research Center on AgingUniversity of SherbrookeSherbrookeCanada
  10. 10.School of Public Health and Health Systems, Schlegel University of Waterloo Research Institute for AgingUniversity of WaterlooWaterlooCanada
  11. 11.Departments of Pharmacology and Medicine (Geriatric Medicine), Faculty of MedicineDalhousie UniversityHalifaxCanada
  12. 12.Department of Surgery and Critical Care MedicineUniversity of AlbertaEdmontonCanada
  13. 13.Robert and Arlene Kogod Center on AgingMayo ClinicRochesterUSA
  14. 14.Department of GeriatricsHospital Universitario de GetafeMadridSpain
  15. 15.Fondazione Policlinico Universitario «Agostino Gemelli» IRCCSUniversitá Cattolica del Sacro CuoreRomeItaly
  16. 16.Department of Health Research Methods, Evaluation and ImpactMcMaster UniversityHamiltonCanada
  17. 17.Division of Geriatric MedicineDalhousie UniversityHalifaxCanada
  18. 18.Foundation for Diabetes Research in Older People at Diabetes Frail LtdLutonUK
  19. 19.Schwartz/Reisman Emergency Medicine Institute, Mount Sinai HospitalUniversity of TorontoTorontoCanada
  20. 20.Division of Emergency MedicineMcMaster UniversityHamiltonCanada
  21. 21.Fundación de Investigación Biomédica Hospital Universitario de Getafe, Getafe, Spain. Dept. of Epidemiology and BiostatisticsUniversity of CaliforniaSan FranciscoUSA
  22. 22.Kingston Health Sciences CentreKingstonCanada

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