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Anti-Tau Trials for Alzheimer’s Disease: A Report from the EU/US/CTAD Task Force

  • Jeffrey CummingsEmail author
  • K. Blennow
  • K. Johnson
  • M. Keeley
  • R. J. Bateman
  • J. L. Molinuevo
  • J. Touchon
  • P. Aisen
  • B. Vellas
  • EU/US/CTAD Task Force
CTAD Task Force Paper
  • 1 Downloads

Abstract

Efforts to develop effective disease-modifying treatments for Alzheimer’s disease (AD) have mostly targeted the amyloid β (Aβ) protein; however, there has recently been increased interest in other targets including phosphorylated tau and other forms of tau. Aggregated tau appears to spread in a characteristic pattern throughout the brain and is thought to drive neurodegeneration. Both neuropathological and imaging studies indicate that tau first appears in the entorhinal cortex and then spreads to the neocortex. Anti-tau therapies currently in Phase 1 or 2 trials include passive and active immunotherapies designed to prevent aggregation, seeding, and spreading, as well as small molecules that modulate tau metabolism and function. EU/US/CTAD Task Force members support advancing the development of anti-tau therapies, which will require novel imaging agents and biomarkers, a deeper understanding of tau biology and the dynamic interaction of tau and Aβ protein, and development of multiple targets and candidate agents addressing the tauopathy of AD. Incorporating tau biomarkers in AD clinical trials will provide additional knowledge about the potential to treat AD by targeting tau.

Key words

Alzheimer’s disease tau tauopathy therapeutics biomarkers 

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Copyright information

© Serdi and Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Jeffrey Cummings
    • 1
    Email author
  • K. Blennow
    • 2
  • K. Johnson
    • 3
  • M. Keeley
    • 4
  • R. J. Bateman
    • 5
  • J. L. Molinuevo
    • 6
  • J. Touchon
    • 7
  • P. Aisen
    • 8
  • B. Vellas
    • 9
  • EU/US/CTAD Task Force
  1. 1.University of Nevada Las Vegas, School of Allied Health Sciences and Cleveland Clinic Lou Ruvo Center for Brain HealthLas VegasUSA
  2. 2.Inst. of Neuroscience and PhysiologyUniversity of Gothenburg, Sahlgrenska University HospitalMölndalSweden
  3. 3.Massachusetts General Hospital, Harvard Medical SchoolBostonUSA
  4. 4.Genentech Research and Early Development, So.San FranciscoUSA
  5. 5.Washington University School of MedicineSt. LouisUSA
  6. 6.BarcelonaBeta Brain Research Center Pasqual Maragall FoundationBarcelonaSpain
  7. 7.INSERM U1061Montpellier UniversityMontpellierFrance
  8. 8.Alzheimer’s Therapeutic Research Institute (ATRI), Keck School of MedicineUniversity of Southern CaliforniaSan DiegoUSA
  9. 9.Gerontopole, INSERM U1027, Alzheimer’s Disease Research and Clinical CenterToulouse University HospitalToulouseFrance

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