Nanorobots the Future of Neurology: A Perspective on Alzheimer’s Disease

  • Claudie HooperEmail author
  • S. Layé
Letter to Editor


  1. 1.
    Balasubramanian S, Kagan D, Hu C-MJ, Campuzano S, Lobo-Castañon MJ, Lim N, et al. (2011) Micromachine-enabled capture and isolation of cancer cells in complex media. Angew. Chem. Int. Ed. Engl. 50(18):4161–4.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Gao W, Dong R, Thamphiwatana S, Li J, Gao W, Zhang L, et al. (2015) Artificial micromotors in the mouse’s stomach: a step toward in vivo use of synthetic motors. ACS Nano. 9(1):117–23.CrossRefPubMedGoogle Scholar
  3. 3.
    Barnes JC, Mirkin CA. (2017) Profile of Jean-Pierre Sauvage, Sir J Fraser Stoddart, and Bernard L. Feringa, 2016 Nobel Laureates in Chemisry. Proc. Natl. Acad. Sci. USA. 114(4):620–5Google Scholar
  4. 4.
    DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM. (2001) Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer’s disease. Proc Natl Acad Sci U S A. 98(15):8850–5.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Layé S, Nadjar A, Joffre C, Bazinet RP. (2017) Anti-inflammatory effects of omega 3 fatty acids in the brain: Physiological mechanisms and relevance to pharmacology. Pharm Rev. In press.Google Scholar
  6. 6.
    Hooper C, De Souto Barreto P, Payoux P, Salabert AS, Guyonnet S, Andrieu S, et al. (2017) Croßs-sectional associations of cortical β-amyloid with erythrocyte membrane long-chain polyunsaturated fatty acids in older adults with subjective memory complaints. J Neurochem. 142:589–96.CrossRefPubMedGoogle Scholar
  7. 7.
    Hooper C., De Souto Barreto P., Payoux P., Salabert A. S., Guyonnet S., Andrieu S., Vellas B. (2017) Association of cortical B-amyloid with erythrocyte membrane monounsaturated and saturated fatty acids in older adults at risk of dementia. J Nutr. Health Aging. 21(10):1170–1175.CrossRefPubMedGoogle Scholar
  8. 8.
    Mosconi L, Murray J, Davies M, Williams S, Pirraglia E, Spector N, et al. (2014) Nutrient intake and brain biomarkers of Alzheimer’s disease in at-risk cognitively normal individuals: a cross-sectional neuroimaging pilot study. BMJ Open. 4(6):e004850.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Morris JK, Vidoni ED, Wilkins HM, Archer AE, Burns NC, Karcher RT, et al. (2016) Impaired fasting glucose is associated with increased regional cerebral amyloid. Neurobiol. Aging. 44:138–42.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Morris JK, Vidoni ED, Honea RA, Burns JM. (2014) Impaired glycemia increases disease progression in mild cognitive impairment. Neurobiol. Aging. 35(3):585–9.CrossRefPubMedGoogle Scholar
  11. 11.
    Cederholm T, Salem N, Palmblad J. (2013) ω-3 fatty acids in the prevention of cognitive decline in humans. Adv Nutr. 4(6):672–6.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Feart C, Helmer C, Merle B, Herrmann FR, Annweiler C, Dartigues J-F, et al. (2017) Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer’s disease in older adults. Alzheimers Dement. 13(11):1207–16.CrossRefPubMedGoogle Scholar
  13. 13.
    Smith AD, Refsum H. (2017) Dementia prevention by disease-modification through nutrition. J.Prev. Alz. Dis. 4(3):138–9.Google Scholar
  14. 14.
    Hooper C, De Souto Barreto P, Pahor M, Weiner M, Vellas B. (2017) The relationship of omega 3 polyunsaturated fatty acids in red blood cell membranes with cognitive function and brain structure: A review focussed on Alzheimer’s disease. J. Prev. of Alz. Dis. 19.Google Scholar

Copyright information

© Serdi and Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Gérontopôle, Department of GeriatricsCHU Toulouse, Purpan University HospitalToulouseFrance
  2. 2.INRA, Nutrition et Neurobiologie Intégrée, UMR 1286BordeauxFrance

Personalised recommendations