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Role of chemokines in ischemic neuronal stress

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Abstract

Chemokines constitute a large family of structurally related small cytokines originally identified as the factors regulating the migration of leukocytes in inflammatory and immune responses. Enhanced production and release of chemokines are observed also in the central nervous system under diverse neuronal stresses including ischemia, axonal injury, and neurotoxic substances such as an Aβ-peptide. There is growing evidence that brain chemokines play crucial roles in the neuro-glio-vascular interaction underlying the pathology of various brain disorders. Here the evidence of the involvement of chemokines in ischemic brain injury is reviewed.

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Authors and Affiliations

  1. Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 606-8501, Kyoto, Japan

    Masabumi Minami

  2. Nara Institute of Science and Technology, 630-0101, Ikoma, Japan

    Masamichi Satoh

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  1. Masabumi Minami
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  2. Masamichi Satoh
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Correspondence to Masabumi Minami.

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Minami, M., Satoh, M. Role of chemokines in ischemic neuronal stress. Neuromol Med 7, 149–155 (2005). https://doi.org/10.1385/NMM:7:1-2:149

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  • DOI: https://doi.org/10.1385/NMM:7:1-2:149

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