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Apoptosis and traumatic brain injury

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Abstract

Traumatic brain injury is a cause of high mortality and morbidity and is an area of intense research. Apoptosis plays a crucial role in the pathogenesis of head injury, and the inhibition of apoptosis can potentially reverse the deleterious effects and lead to better functional outcome. Elucidation of the apoptotic pathway and its role in traumatic brain injury will provide potential targets for therapeutic intervention. This article aims to review the current wealth of literature on apoptosis and traumatic head injury and explores the current status of therapeutic strategies available.

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Authors and Affiliations

  1. Acute Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, Singapore

    Jill Wong, Ng Wai Hoe & Ivan Ng

  2. Department of Research, National Neuroscience Institute, Singapore

    Feng Zhiwei

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  1. Jill Wong
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  2. Ng Wai Hoe
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  3. Feng Zhiwei
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  4. Ivan Ng
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Correspondence to Ivan Ng.

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Wong, J., Hoe, N.W., Zhiwei, F. et al. Apoptosis and traumatic brain injury. Neurocrit Care 3, 177–182 (2005). https://doi.org/10.1385/NCC:3:2:177

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