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Biomimetic design of nanopatterned membranes

  • Original Article
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NanoBiotechnology

Abstract

The biomimetic approach copying the supramolecular building principle of many archaeal cell envelopes (i.e., a plasma membrane with associated S-layer proteins) has resulted in stable lipid membranes with excellent reconstitution properties for transmembrane proteins. This is a particular challenge as one-third of all proteins in an organism are membrane proteins like pores, ion channels, or receptors. At S-layer supported lipid membranes, spatial well-defined domains on the S-layer protein interact noncovalently with lipid head groups within the lipid membrane resulting in a nanopatterning of a few anchored and scores of diffusional free-lipid molecules. In addition, no impact on the hydrophobic core region and on the function of reconstituted integral proteins has been determined. Among others, particularly S-layer stabilized membranes can be used for structure-function studies on reconstituted integral proteins and also in the membrane protein-based molecular nanotechnology, e.g., in the design of biosensing devices (e.g., lipid chip or lab-on-a-chip), or for receptor or ion channel-based high-throughput screening.

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  1. Center for NanoBiotechnology, BOKU - University of Natural Resources and Applied Life Sciences Vienna, Gregor-Mendel-Strasse 33, 1180, Vienna, Austria

    Bernhard Schuster

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  1. Bernhard Schuster
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Schuster, B. Biomimetic design of nanopatterned membranes. Nanobiotechnol 1, 153–164 (2005). https://doi.org/10.1385/NBT:1:2:153

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