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Pemetrexed-induced acute renal failure, nephrogenic diabetes insipidus, and renal tubular acidosis in a patient with non-small cell lung cancer

Medical Oncology volume 23, pages 419–422 (2006)Cite this article

Abstract

We report a patient with metastatic non-small cell lung cancer who developed renal toxicities manifest as acute renal failure associated with nephrogenic diabetes insipidus and distal renal tubular acidosis following sequential therapy with pemetrexed. The nephrotoxicity occurred concomitantly with severe myelosuppression. We postulate renal tubular toxicity may account for distinct patterns of injury including acute renal failure and tubular cell dysfuntion of the distal nephron.

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Author information

Affiliations

  1. Department of Internal Medicine, Rochester General Hospital, Rochester, NY

    Vidya Vootukuru

  2. Department of Nephrology & Hypertension, Cleveland Clinic Foundation, 9500 Euclid Avenue-Desk A51, 44195, Cleveland, OH

    Yin Ping Liew & Joseph V. Nally Jr. MD

Authors
  1. Vidya Vootukuru
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  2. Yin Ping Liew
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  3. Joseph V. Nally Jr. MD
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Corresponding author

Correspondence to Joseph V. Nally Jr. MD.

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Vootukuru, V., Liew, Y.P. & Nally, J.V. Pemetrexed-induced acute renal failure, nephrogenic diabetes insipidus, and renal tubular acidosis in a patient with non-small cell lung cancer. Med Oncol 23, 419–422 (2006). https://doi.org/10.1385/MO:23:3:419

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  • DOI: https://doi.org/10.1385/MO:23:3:419

Key Words

  • Pemetrexed
  • acute renal failure
  • renal tubular acidosis
  • nephrogenic diabetes insipidus