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Mantle cell lymphoma presenting with paraproteinemia

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Abstract

Mantle cell lymphoma (MCL) is most frequently diagnosed by the routine histological (HP) and immunohistochemical (IH) examination. Herein we present a case of 47-yr-old female with general lymphadenopathy and leukemic blood picture. She was initially diagnosed with marginal zone lymphoma (MZL). This diagnosis was based not only on the HP/IH examination but also on the presence of IgM paraproteinemia. Flow cytometry (FCM) examination was helpful in making of the final diagnosis of MCL. Fluorescence in situ hybridization and cyclin D1 mRNA detection by RT-PCR additionally confirmed the MCL diagnosis. The IgM paraproteinemia is rare in MCL, although is a common feature of lymphoplasmacytoid lymphomas (LPL) and is considered a major characteristic of Waldenström’s macroglobulinemia (WM).

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Authors and Affiliations

  1. Department of Pathology, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute, Warsaw, Poland

    Grzegorz Rymkiewicz MD & Katarzyna Błachnio

  2. Department of Hemato-Oncology, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute, Warsaw, Poland

    Anna Borawska & Jan Walewski

  3. Cytogenetic Laboratory, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute, Warsaw, Poland

    Renata Woroniecka & Barbara Pieńkowska-Grela

  4. Department of Cell Biology, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute, Warsaw, Poland

    Monika Gos, Paweł Swoboda & Przemysław Janik

  5. The Medical University of Warsaw, Poland

    Marika Kulińska

Authors
  1. Grzegorz Rymkiewicz MD
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  2. Monika Gos
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  3. Katarzyna Błachnio
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  4. Renata Woroniecka
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  6. Barbara Pieńkowska-Grela
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  8. Anna Borawska
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  10. Jan Walewski
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Correspondence to Grzegorz Rymkiewicz MD.

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Rymkiewicz, G., Gos, M., Błachnio, K. et al. Mantle cell lymphoma presenting with paraproteinemia. Med Oncol 22, 319–323 (2005). https://doi.org/10.1385/MO:22:3:319

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  • DOI: https://doi.org/10.1385/MO:22:3:319

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