Skip to main content

Advertisement

Log in

Primary non-Hodgkin’s lymphoma of the transverse colon presenting as dermatomyositis

Case presentation and literature review

  • Case Report
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

Primary extranodal non-Hodgkin’s lymphoma of the transverse colon is a rare presentation of non-Hodgkin’s lymphoma or colonic neoplasm. Dermatomyositis is an autoimmune condition of the skin, muscle, and blood vessels that when associated with malignancy is a true paraneoplastic syndrome but is rarely associated with non-Hodgkin’s lymphoma. We present a case of primary non-Hodgkin’s lymphoma of the transverse colon diagnosed after the presentation of dermatomyositis and review the literature on dermatomyositis and hematologic neoplasm.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Arnold, S., Patchell, R., Lowy, A. and Foon, K. (1995). Paraneoplastic syndromes, in Cancer: Principles and Practice of Oncology, 6th ed. (DeVita, V., Hellman, S. and Rosenberg, S., eds.), p. 2524, Lippincott, Williams, & Wilkins, Philadelphia.

    Google Scholar 

  2. Hill, C., et al. (2001). Frequency of specific cancer types in dermatomyositis and polymyositis: a population based study. Lancet 357:96–100.

    Article  PubMed  CAS  Google Scholar 

  3. Bohan, A. and Peter, J. (1975). Polymyositis and dermatomyositis. N. Engl. J. Med. 292:344–347.

    Article  PubMed  CAS  Google Scholar 

  4. Barnes, B. (1976). Dermatomyositis and malignancy: a review of the literature. Ann. Intern. Med. 84:68–76.

    PubMed  CAS  Google Scholar 

  5. Jemal, A., Thomas, A., Murray, T. and Thun, M. (2002). Cancer statistics, 2002. CA Cancer J. Clin. 52:23–47.

    PubMed  Google Scholar 

  6. d’Amore, F., et al. (1994). Non-Hodgkin’s lymphoma of the gastrointestinal tract: a population based analysis of incidence, geographic distribution, clinicopathologic presentation features, and prognosis. J. Clin. Oncol. 12:1673–1684.

    PubMed  CAS  Google Scholar 

  7. Cho, M., et al. (1997). Primary non-Hodgkin’s lymphoma of the large bowel. Radiology 205:535–539.

    PubMed  CAS  Google Scholar 

  8. Crump, M., Gospodarowicz, M. and Sheperd, F. (1999). Lymphoma of the gastrointestinal tract. Semin. Oncol. 26:324–337.

    PubMed  CAS  Google Scholar 

  9. Richards, M. (1986). Lymphoma of the colon and rectum. Postgrad. Med. J. 62:615–620.

    PubMed  CAS  Google Scholar 

  10. Chandran, R., Raj, E. and Chaturvedi, H. (1995). Primary gastrointestinal lymphoma: 30 year experience at the cancer institute, Madras, India. J. Surg. Oncol. 60:41–49.

    Article  PubMed  CAS  Google Scholar 

  11. Contreary, K., Nance, F. and Becker, W. (1980). Primary lymphoma of the gastrointestinal tract. Ann. Surg. 191:593–598.

    Article  PubMed  CAS  Google Scholar 

  12. Dragosics, B., Bauer, P. and Radaszkiewicz, T. (1985). Primary gastrointestinal non-Hodgkin’s lymphomas: a retrospective clinicopathologic study of 150 cases. Cancer 55:1060–1073.

    Article  PubMed  CAS  Google Scholar 

  13. Ducreux, M., Boutron, M.-C., Piard, F., Carli, P.-M. and Faivre, J. (1998). A 15-year series of gastrointestinal non-Hodgkin’s lymphomas: a population based study. Br. J. Cancer 77:511–514.

    PubMed  CAS  Google Scholar 

  14. Loehr, W., Mujahed, Z., Zahn, D., Gray, G. and Thorbjarnarson, B. (1969). Primary lymphoma of the gastrointestinal tract: a review of 100 cases. Ann. Surg. 170:232–238.

    Article  PubMed  CAS  Google Scholar 

  15. Morton, J., et al. (1993). Primary gastrointestinal non-Hodgkin’s lymphoma: a review of 175 British National Lymphoma investigation cases. Br. J. Cancer 67:776–782.

    PubMed  CAS  Google Scholar 

  16. Novak, S., Caraveo, J., Trowbridge, A., Peterson, R. and White, R. (1979). Primary lymphomas of the gastrointestinal tract. South. Med. J. 72:1154–1158.

    PubMed  CAS  Google Scholar 

  17. Sanchez-Bueno, F., et al. (1998). Prognostic factors in primary gastrointestinal non-Hodgkin’s lymphoma: a multivariate analysis of 76 cases. Eur. J. Surg. 164:385–392.

    Article  PubMed  CAS  Google Scholar 

  18. Tedeschi, L., et al. (1994). Stages I and II non-Hodgkin’s lymphoma of the gastrointestinal tract. J. Clin. Gastroenterol. 18:99–104.

    Article  PubMed  CAS  Google Scholar 

  19. Weingrad, D., et al. (1982). Primary gastrointestinal lymphoma: a 30 year review. Cancer 49:1258–1265.

    Article  PubMed  CAS  Google Scholar 

  20. Doolabh, N., et al. (2000). Primary colonic lymphoma. J. Surg. Oncol. 74:257–262.

    Article  PubMed  CAS  Google Scholar 

  21. Glick, D. and Soule, E. (1966). Primary malignant lymphoma of colon or appendix. Arch. Surg. 92:144–151.

    PubMed  CAS  Google Scholar 

  22. Henry, C. and Berry, R. (1988). Primary lymphoma of the large intestine. The American Surgeon 54:262–266.

    PubMed  CAS  Google Scholar 

  23. Pandey, M., et al. (2002). Primary malignant large bowel lymphoma. The American Surgeon 68:121–126.

    PubMed  Google Scholar 

  24. Wychulis, A., Beahrs, O. and Woolner, L. (1966). Malignant lymphoma of the colon. Arch. Surg. 93:215–225.

    PubMed  CAS  Google Scholar 

  25. Zighelboim, J. and Larson, M. (1994). Primary colonic lymphoma. Clinical presentation, histopathologic features, and outcome with combination chemotherapy. J. Clin. Gastroenterol. 18:291–297.

    Article  PubMed  CAS  Google Scholar 

  26. Zinzani, P., et al. (1997). Primary intestinal lymphoma: clinical and therapeutic features of 32 patients. Haematologica 82:305–308.

    PubMed  CAS  Google Scholar 

  27. Skibber, J., Minsky, B. and Hoff, P. (2001). Cancer of the colon, in Cancer: Principles and Practice of Oncology, 6th ed. (DeVita, V., Hellman, S. and Rosenberg, S., eds.), p1227, Lippincott, Williams, & Wilkins, Philadelphia.

    Google Scholar 

  28. Herrman, R., Panahon, A., Barcos, M., Walsh, D. and Stutzman, L. (1980). Gastrointestinal involvement in Non-Hodgkin’s Lymphoma. Cancer 46:215–222.

    Article  Google Scholar 

  29. Armitage, J., Maugh, P., Harris, N. and Bierman, P. (2001). Non-Hodgkin’s lymphoma, in Cancer: Principles and Practice of Oncology, 6th ed. DeVita, V., Hellman, S. and Rosenberg, S., (eds.), pp2258–2259, Lippincott, Williams, & Wilkins, Philadelphia.

    Google Scholar 

  30. Bittar, B. and Rose, C. (1995). Early development of Hodgkin’s lymphoma in association with the use of methotrexate for the treatment of dermatomyositis. Ann. Rheum. Dis. 54:607–608.

    PubMed  CAS  Google Scholar 

  31. Kamel, O., et al. (1994). Lymphoid neoplasms in patients with rheumatoid arthritis and dermatomyositis: frequency of Epstein-Barr virus and other features associated with immunosuppression. Hum. Pathol. 25:638–643.

    Article  PubMed  CAS  Google Scholar 

  32. McNutt, N., Smoller, B. and Contreras, F. (1996). Skin, in Anderson’s Pathology, 10th ed. (Damjanov, I. and Linder, J., eds.), pp2425–2426, Mosby, St. Louis, MO.

    Google Scholar 

  33. Heffner, R. and Schochet, S. (1996). Skeletal muscle, in Anderson’s Pathology, 10th ed. (Damjanov I. and Linder, J., eds.), pp2668–2669, Mosby, St. Louis, MO.

    Google Scholar 

  34. Rowell, N. and Goodfield, M. (1998). The “connective tissue diseases”—dermatomyositis, in Rook/Wilkinson/Eberling Textbook of Dermatology, 6th ed. (Champion, R., Burton, J., Burns, D. and Breathnach, S., eds.), pp2555–2565, Blackwell Science, London.

    Google Scholar 

  35. Euwer, R. and Sontheimer, R. (1991). Amyopathic dermatomyositis (dermatomyositis sine myositis). Presentation of six new cases and review of the literature. J. Am. Acad. Dermatol. 24(6Pt. 1):959–966.

    Article  PubMed  CAS  Google Scholar 

  36. Manchul, L., et al. (1985). The frequency of malignant neoplasms in patients with polymyositis-dermatomyositis. A controlled study. Arch. Intern. Med. 145:1835–1839.

    Article  PubMed  CAS  Google Scholar 

  37. Sigurgeirsson, B., Lindelöf Edhag, O. and Allander, E. (1992). Risk of cancer in patients with dermatomyositis or polymyositis. A population based study. N. Engl. J. Med. 326:363–367.

    Article  PubMed  CAS  Google Scholar 

  38. Anzai, S., Katagiri, K., Sato, T. and Takayasu, S. (1997). Dermatomyositis associated with primary intramuscular B cell lymphoma. J. Dermatol. 24:649–653.

    PubMed  CAS  Google Scholar 

  39. Miller, D. (1967). The association of immune disease and malignant lymphoma. Ann. Intern. Med. 66:507.

    PubMed  CAS  Google Scholar 

  40. Beck, P. (1968). Myelomatosis presenting as dermatomyositis. Br. Med. J. 1:747–748.

    Article  PubMed  CAS  Google Scholar 

  41. Connor, B. (1972). Mycosis fungoides with dermatomyositis. Proc. R. Soc. Med. 65:251–252.

    PubMed  CAS  Google Scholar 

  42. Wishart, J. (1973). Reticulosarcoma of vulva complicating azathioprine-treated dermatomyositis. Arch. Dermatol. 108:563–564.

    Article  PubMed  CAS  Google Scholar 

  43. Zilko, P. and Dawkins, R. (1975). Amyloidosis associated with dermatomyositis and features of multiple myeloma. Am. J. Med. 59:448–452.

    Article  PubMed  CAS  Google Scholar 

  44. Dowsett, R., Wong, R., Robert, N. and Abeles, M. (1986). Dermatomyositis and Hodgkin’s disease. Case report and review of the literature. Am. J. Med. 80:719–723.

    Article  PubMed  CAS  Google Scholar 

  45. Yamamura, T., Tsujimura, M., Yoshikawa, K. and Aozasa, K. (1987). True histiocytic lymphoma associated with dermatomyositis. Arch. Dermatol. 122:1272–1274.

    Article  Google Scholar 

  46. Cox, N. and Lawrence, C. (1988). Dermatomyositis and lymphoma. Arch. Dermatol. 124:487.

    Article  PubMed  CAS  Google Scholar 

  47. Caron, P., Lassoued, S., Thibault, I., Fournie, B. and Fournie, A. (1989). Thyroid plasmacytoma with dermatomyositis and palmar fasciitis. J. Rheum. 16:997–999.

    PubMed  CAS  Google Scholar 

  48. Shay, M., Braester, A. and Cohen, I. (1991). Dermatomyositis as presenting symptom of Hodgkin’s disease. Ann. Hematol. 63:116–118.

    Article  PubMed  CAS  Google Scholar 

  49. Schulman, P., Kerr, L. and Spiera, H. (1991). A reexamination of the relationship between myositis and malignancy. J. Rheum. 18:1689–1692.

    PubMed  CAS  Google Scholar 

  50. Cheng, W., Alagaratnam, T., Leung, C. and Chan, A. (1993). Tuberculosis and lymphoma of the breast in a patient with dermatomyositis. Aust. NZ J. Surg. 63:660–661.

    CAS  Google Scholar 

  51. Rahman, M., Eagle, K., Rosenberg, J. and Black, C. (1994). A case of non-Hodgkin’s lymphoma in a patient presenting with dermatomyositis. Br. J. Rheum. 33:500–501.

    Article  CAS  Google Scholar 

  52. Ishida, T., et al. (1995). Chronic lymphocytic leukemia associated with nephritic syndrome and dermatomyositis. Intern. Med. 34:15–17.

    PubMed  CAS  Google Scholar 

  53. Osman, Y., et al. (1996). Case report: amyopathic dermatomyositis associated with transformed malignant lymphoma. Am. J. Med. Sci. 311: 240–242.

    Article  PubMed  CAS  Google Scholar 

  54. Federman, D., Kirsner, R. and Braverman, I. (1997). A patient with cutaneous T-cell lymphoma and dermatomyosistis. Cutis 59:277.

    PubMed  CAS  Google Scholar 

  55. Kojima, M., et al. (1997). Malignant lymphoma in patients with rheumatic diseases other than Sjogren’s syndrome: a clinicopathologic study of five cases and a review of the Japanese literature. Jpn. J. Clin. Oncol. 27:84–90.

    Article  PubMed  CAS  Google Scholar 

  56. Hashefi, M., et al. (2000). Seropositive rheumatoid arthritis with dermatomyositis sine myositis, angioimmunoblastic lymphadenopathy with dysproteinemia-type T cell lymphoma, and B cell lymphoma of the oropharynx. J. Rheum. 27:1087–1090.

    PubMed  CAS  Google Scholar 

  57. Borgia, F., Vaccaro, M., Guaraneri, F., Cannavo, S. and Guarneri, B. (2001). Dermatomyositis associated with IgG myeloma. Br. J. Dermatol. 144:200–201.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Joseph R. Salvatore.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Salvatore, J.R., Sarid, R., Harrington, J. et al. Primary non-Hodgkin’s lymphoma of the transverse colon presenting as dermatomyositis. Med Oncol 20, 413–424 (2003). https://doi.org/10.1385/MO:20:4:413

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1385/MO:20:4:413

Key Words

Navigation