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High prevalence of MMTV-like env gene sequences in gestational breast cancer

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Abstract

Gestational breast cancer (BC) is generally associated with rapid growth and increased mortality. Because the presence of MMTV-like sequences in BC has been associated with laminin receptor expression, a marker of poor prognosis, gestational BCs were analyzed for MMTV env gene-like sequences to explore whether MMTV-like sequences were also associated with its adverse outcome. Whereas 30–38% of sporadic BC have the sequences, in gestational BC the prevalence is 62%. We suggest that hormonal response elements present in the MMTV-like LTR may play a role in promoting cell growth, as they do in the mouse system.

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Authors and Affiliations

  1. Department of Medicine, The Mount Sinai School of Medicine, New York, New York

    Y. Wang, S. M. Melana, B. Baker, M. Fernandez-Cobo, J. F. Holland & B. G. T. Pogo

  2. Department of Pathology, The Mount Sinai School of Medicine, New York, New York

    I. Bleiweiss

  3. Biomathematical Sciences, The Mount Sinai School of Medicine, New York, New York

    J. F. Mandeli

  4. Department of Microbiology, The Mount Sinai School of Medicine, New York, New York

    B. G. T. Pogo

Authors
  1. Y. Wang
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  2. S. M. Melana
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  3. B. Baker
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  4. I. Bleiweiss
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  5. M. Fernandez-Cobo
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  6. J. F. Mandeli
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  7. J. F. Holland
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  8. B. G. T. Pogo
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Correspondence to B. G. T. Pogo.

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Wang, Y., Melana, S.M., Baker, B. et al. High prevalence of MMTV-like env gene sequences in gestational breast cancer. Med Oncol 20, 233–236 (2003). https://doi.org/10.1385/MO:20:3:233

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  • DOI: https://doi.org/10.1385/MO:20:3:233

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