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Improvement of chronic pulmonary graft-vs-host disease manifesting as bronchiolitis obliterans organizing pneumonia following extracorporeal photopheresis

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Abstract

Despite use of combined immunosuppressive agents, prognosis of patients developing pulmonary manifestations of chronic graft-vs-host disease (cGVHD) following allogeneic stem cell transplantation (SCT) still remains poor. We present a male patient who developed pulmonary cGVHD in the form of bronchiolitis obliterans organizing pneumonia (BOOP) following allogeneic SCT for acute myelogenous leukemia. The patient developed progressive course despite use of a combination of immunosuppressive agents including high-dose prednisone, cyclosporin-A, and mycophenolate mofetil in addition to steroid-related complications. A remarkable clinical response to extracorporeal photopheresis (ECP) was observed, allowing minimization of immunosuppressive therapy and discontinuation of cyclosporin-A. Pulmonary functions and carbon monoxide diffusion capacity (DLCO) gradually improved and stabilized, but did not return to pretransplant baseline levels.

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Authors and Affiliations

  1. Department of Medical Oncology, Institute of Oncology, Hacettepe University, 06100, Ankara, Turkey

    Basak Oyan, Yener Koc (Associate Professor Hematology/Oncology) & Emin Kansu

  2. Department of Respiratory Diseases, Institute of Oncology, Hacettepe University, 06100, Ankara, Turkey

    Salih Emri

  3. Faculty of Medicine, Hacettepe University, 06100, Ankara, Turkey

    Salih Emri

Authors
  1. Basak Oyan
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  2. Yener Koc
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  3. Salih Emri
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  4. Emin Kansu
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Correspondence to Yener Koc.

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Oyan, B., Koc, Y., Emri, S. et al. Improvement of chronic pulmonary graft-vs-host disease manifesting as bronchiolitis obliterans organizing pneumonia following extracorporeal photopheresis. Med Oncol 23, 125–129 (2006). https://doi.org/10.1385/MO:23:1:125

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  • DOI: https://doi.org/10.1385/MO:23:1:125

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