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ALK-negative T-cell anaplastic large cell lymphoma associated with systemic lupus erythematosus

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Abstract

Patients with systemic lupus erythematosus (SLE) appear to have an increased risk of developing malignancies, especially lymphomas. We report the development of a systemic ALK-negative T-cell anaplastic large cell lymphoma, stage IIB, in a 53-yr-old Caucasian female with a 12-yr history of stable SLE. The patient responded poorly to chemotherapy and died 2 yr after diagnosis. Lymphomas that develop in patients with SLE and other autoimmune diseases are virtually always of B-cell origin. To our knowledge this is the first report of a T-cell anaplastic large cell lymphoma in a patient with SLE. This article discusses the association of SLE and lymphoma, with an emphasis on T-lymphoproliferative states.

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Authors and Affiliations

  1. Institute of Rheumatology, Belgrade and Montenegro, Serbia

    Roksanda Stojanovic-Milenkovic

  2. Institute of Radiology and Oncology, Belgrade and Montenegro, Serbia

    Zoran Tomasevic

  3. Imperial College Medical School, Hammersmith Hospital, Du Cane Road, London, UK

    Henry D. E. Atkinson

  4. Institute of Hematology, Clinical Center of Serbia, 2, Koste Todorovic str., 11000, Belgrade and Montenegro, Serbia

    Nada Suvajdzic MD, Vesna Cemerikic-Martinovic & Biljana Mihaljevic

Authors
  1. Nada Suvajdzic MD
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  2. Roksanda Stojanovic-Milenkovic
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  3. Zoran Tomasevic
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  4. Vesna Cemerikic-Martinovic
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  5. Biljana Mihaljevic
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  6. Henry D. E. Atkinson
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Correspondence to Nada Suvajdzic MD.

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Suvajdzic, N., Stojanovic-Milenkovic, R., Tomasevic, Z. et al. ALK-negative T-cell anaplastic large cell lymphoma associated with systemic lupus erythematosus. Med Oncol 20, 409–412 (2003). https://doi.org/10.1385/MO:20:4:409

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  • DOI: https://doi.org/10.1385/MO:20:4:409

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