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Medical Oncology

, Volume 19, Issue 3, pp 189–192 | Cite as

Microangiopathic hemolysis refractory to plasmapheresis responding to docetaxel and cisplatin

A case report
  • George MarcoullisEmail author
  • Lool Abebe
  • Dharamvir Jain
  • Richard Talusan
  • Niyati Bhagwati
  • Peter H. Wiernik
Case Report

Abstract

We report the case of a 56-yr-old woman with adenocarcinoma of unknown origin metastatic to the bone marrow presenting with a thrombotic thrombocytopenic purpura-like syndrome refractory to protracted daily plasmapheresis and steroids but readily and completely responsive to docetaxel plus cisplatin. Sustained and complete response was pathologically confirmed.

Key Words

Adenocarcinoma of unknown origin thrombotic thrombocytopenic purpura taxanes cisplatin plasma exchange protein-A immunoadsorption alkylating agents 

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Copyright information

© Humana Press Inc 2002

Authors and Affiliations

  • George Marcoullis
    • 1
    Email author
  • Lool Abebe
    • 2
  • Dharamvir Jain
    • 1
  • Richard Talusan
    • 1
  • Niyati Bhagwati
    • 1
  • Peter H. Wiernik
    • 1
  1. 1.Comprehensive Cancer Center Our Lady of Mercy Medical CenterNew York Medical CollegeBronx
  2. 2.Department of Pathology, Our Lady of Mercy Medical CenterNew York Medical CollegeBronx

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