Medical Oncology

, Volume 19, Issue 3, pp 167–169 | Cite as

Leptomeningeal infiltration of malignant mesothelioma

  • Berna Öksüzoğlu
  • Şuayib Yalçin
  • Mustafa ErmanEmail author
  • Selçuk Dağdelen
Case Report


Mesothelioma is a disease mostly involving the pleura, peritoneum, and pericardium. Hematogenously disseminated metastases involving the liver, adrenal glands, kidneys, and contralateral lung have been documented in some patients, but central nervous system (CNS) involvement, especially as leptomeningeal infiltration, is very rare. A 44-yr-old mesothelioma patient admitted to hospital with convulsions and diffuse leptomeningeal infiltration was shown with magnetic resonance imaging. She had a positive history for environmental asbestos exposure. Pleural and axillary lymph node biopsies were consistent with mesothelioma. Diffuse leptomeningeal infiltration is the only constant radiological finding reported as a diagnostic criteria for CNS involvement and histopathological confirmation is usually possible only at autopsy, so clinical and radiological diagnosis is essential after exclusion of other possible causes.

Key Words

Mesothelioma central nervous system 


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  1. 1.
    Kaye, J.A., Wang, A., Joachim, C.L., et al. (1986). Malignant mesothelioma with brain metastases. Am. J. Med. 80, 95–97.PubMedCrossRefGoogle Scholar
  2. 2.
    Artvinli, M. and Bariş, Y.I. (1979). Malignant pleural mesothelioma in a small village in the Anatolian region of Turkey. An epidemiologic study. J. Natl. Cancer Inst. 63, 17–19.PubMedGoogle Scholar
  3. 3.
    Kawai, A., Nagasaka, Y., Muraki, M., et al. (1997). Brain metastasis in malignant pleural mesothelioma. Intern. Med. 36, 591–594.PubMedGoogle Scholar
  4. 4.
    Murray, J.B., Neilly, J.B., Hadley, D., et al. (1990). Diffuse meningeal thickening associated with pleural mesothelioma. Thorax 45, 70–71.PubMedGoogle Scholar
  5. 5.
    Huncharek, M. and Muscat, J. (1987). Metastases in diffuse pleural mesothelioma: influence of histopathological type. Thorax 42, 897–898.PubMedCrossRefGoogle Scholar
  6. 6.
    Falconieri, G., Grandi, G., DiBonito, L., et al. (1991). Intracranial metastases from malignant pleural mesothelioma. Arch. Pathol. Lab. Med. 115, 591–595.PubMedGoogle Scholar
  7. 7.
    Huncharek, M. and Muscat, J. (1990). Diffuse meningeal thickening associated with pleural mesothelioma. Thorax 45, 571.PubMedGoogle Scholar
  8. 8.
    Altundag, M.K., Ozisik, Y., Yalcin, S., et al. (2000). Primary low grade B-cell lymphoma of the dura in an immunocompetent patient. J. Exp. Clin. Cancer Res. 19, 249–251.PubMedGoogle Scholar
  9. 9.
    Güllü, I., Yalcin, S., Tekuzman, G., et al. (1993). Tumor markers in effusions: a comparative study of tumor marker levels in sera and effusions, in Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants (Travis, C.C., ed), pp 265–271, Plenum, New York.Google Scholar

Copyright information

© Humana Press Inc 2002

Authors and Affiliations

  • Berna Öksüzoğlu
    • 1
  • Şuayib Yalçin
    • 1
  • Mustafa Erman
    • 1
    Email author
  • Selçuk Dağdelen
    • 1
  1. 1.Institute of Oncology, SihhiyeHacettepe UniversityAnkaraTurkey

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