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Receptor protein tyrosine phosphatase from stem cells to mature glial cells of the central nervous system

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Abstract

The cornerstone of cell signaling is largely based on the phosphorylation state that is defined by the equili-brium of the activity of protein kinases and protein phosphatases. The role of protein tyrosine kinases in brain development, brain tumors, and neurodegenerative diseases was studied extensively, yet, the importance of protein tyrosine phosphatases (PTPs) in the development of glial cells was somewhat neglected. In this review, we have summarized recent findings of PTP expression during development of the central nervous system and the different cell types of the brain, from stem cells to mature glial cells, and highlighted the potential role of these enzymes in neuronal stem cell development, glioblastomas, and myelination.

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  1. Department of Neuroscience, Institut Pasteur, 75724, Paris, France

    Smaragda Lamprianou & Sheila Harroch

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Lamprianou, S., Harroch, S. Receptor protein tyrosine phosphatase from stem cells to mature glial cells of the central nervous system. J Mol Neurosci 29, 241–255 (2006). https://doi.org/10.1385/JMN:29:3:241

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