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Motoneuron injury and repair

New perspectives on gonadal steroids as neurotherapeutics

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Abstract

In this review, we will summarize recent work from our laboratory on the role of gonadal steroids as neuroprotective agents in motoneuron viability following cell stress. Three motoneuron models will be discussed: developing axotomized hamster facial motoneurons (FMNs); adult axotomized mouse FMNs; and immortalized, cultured mouse spinal motoneurons subjected to heat shock. New work on two relevant motoneuron proteins, the survival of motor neuron protein, and neuritinor candidate plasticity-related gene 15, indicates differential steroid regulation of these two proteins after axotomy. The concept of gonadal steroids as cellular stress correction factors and the implications of this for acute neurological injury situations will be presented as well.

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  1. Department of Cell Biology, Neurobiology, and Anatomy, Loyola University of Chicago Stritch School of Medicine, 60153, Maywood, IL

    Julie E. Tetzlaff, Christopher B. Huppenbauer, Lisa Tanzer, Thomas D. Alexander & Kathryn J. Jones

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  1. Julie E. Tetzlaff
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  2. Christopher B. Huppenbauer
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Tetzlaff, J.E., Huppenbauer, C.B., Tanzer, L. et al. Motoneuron injury and repair. J Mol Neurosci 28, 53–64 (2006). https://doi.org/10.1385/JMN:28:1:53

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  • DOI: https://doi.org/10.1385/JMN:28:1:53

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