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Brain injury-dependent expression of activity-dependent neuroprotective protein

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Abstract

Activity-dependent neuroprotective protein (ADNP), a crucial brain development factor, contains a unique sequence, termed NAPVSIPQ, which protects mice against closed head injury (CHI). The aim of this study was to determine whether CHI affects ADNP mRNA expression in the injured brain hemisphere. Male C57JBL/6J mice were subjected to CHI. Brains were removed 5 h, 24 h, 7 d, and 29 d post-CHI. A comparison was made between ADNP mRNA in the injured versus the noninjured hemisphere using real-time polymerase chain reaction. A nonsignificant change (p>0.05) was found 5 h, 24 h, and 7 d post-CHI. However, a significant increase (p < 0.05) in ADNP mRNA expression was detected in the injured cerebral hemisphere 29 d post-CHI. The data presented may be associated with ADNP’s crucial involvement in brain development and response to injury.

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Authors and Affiliations

  1. Department of Clinical Biochemistry, Sackler Medical School, Tel Aviv University, 69978, Tel Aviv, Israel

    Roy Zaltzman & Illana Gozes

  2. Department of Pharmacology, Hadassah Medical Centre, Hebrew University, Jerusalem, Israel

    Alexander Alexandrovich, Sara M. Beni, Victoria Trembovler & Esther Shohami

Authors
  1. Roy Zaltzman
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  2. Alexander Alexandrovich
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  3. Sara M. Beni
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  4. Victoria Trembovler
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  5. Esther Shohami
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  6. Illana Gozes
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Correspondence to Illana Gozes.

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Zaltzman, R., Alexandrovich, A., Beni, S.M. et al. Brain injury-dependent expression of activity-dependent neuroprotective protein. J Mol Neurosci 24, 181–187 (2004). https://doi.org/10.1385/JMN:24:2:181

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  • DOI: https://doi.org/10.1385/JMN:24:2:181

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