Skip to main content
SpringerLink
Log in

Drug discovery

Estrogen-related compounds in mouse models of Alzheimer’s disease

  • Anti-Amyloid
  • Published:
Journal of Molecular Neuroscience Aims and scope Submit manuscript

Abstract

Despite promising epidemiological studies that showed a decreased incidence of Alzheimer disease (AD) in women who used hormone replacement therapy (HRT), the results of the recently released Women’s Health Initiative Memory Study has dampened any enthusiasm for the use of HRT in women to prevent or delay the onset of AD. In this position paper, we review these data, along with our own—using estrogens in a transgenic mouse model of AD—and introduce our current working hypothesis and research.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Behl C., Skutella T., Lezoulac’h F., Post A., et al. (1997) Neuroprotection against oxidative stress by estrogens: structure-activity relationship. Mol. Pharmacol. 51, 535–541.

    PubMed  CAS  Google Scholar 

  • Greenfield J. P., Leung L. W., Cai D., Kaasik K., et al. (2002) Estrogen Lowers alzheimer beta-amyloid generation by stimulating trans-golgi network vesicle biogenesis. J. Biol. Chem. 277, 12128–12136.

    Article  PubMed  CAS  Google Scholar 

  • Levin-Allerhand J. A., Lominska C. E., Wang J., and Smith J. D. (2002) 17α-estradiol and 17β-estradiol treatments are effective in lowering cerebral amyloid-β levels in AβPPSWE transgenic mice. J. Alzheim. Dis., in press.

  • Rossouw J. E., Anderson G. L., Prentice R. L., LaCroix A. Z., et al. (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA 288, 321–333.

    Article  PubMed  CAS  Google Scholar 

  • Shumaker S. A., Reboussin B. A., Espeland M. A., Rapp S. R., et al. (1998) The Women’s Health Initiative Memory Study (WHIMS): a trial of the effect of estrogen therapy in preventing and slowing the progression of dementia. Control Clin. Trials 19, 604–621.

    Article  PubMed  CAS  Google Scholar 

  • Tang M. X., Jacobs D., Stern Y., Marder K., et al. (1996) Effect of oestrogen during menopause on risk and age at onset of Alzheimer’s disease. Lancet 348, 429–432.

    Article  PubMed  CAS  Google Scholar 

  • Vincent B. and Smith J. D. (2000) Effect of estradiol on neuronal Swedish-mutated beta-amyloid precursor protein metabolism: reversal by astrocytic cells. Biochem. Biophys. Res. Commun. 271, 82–85.

    Article  PubMed  CAS  Google Scholar 

  • Xu H., Gouras G. K., Greenfield J. P., Vincent B. et al. (1998) Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat. Med. 4, 447–451.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cell Bology, The Cleveland Clinic Foundation, 44195, Cleveland, OH

    Jonathan D. Smith, Enakshi Chakrabarti & Justine A. Levin-Allerhand

Authors
  1. Jonathan D. Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Enakshi Chakrabarti
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Justine A. Levin-Allerhand
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jonathan D. Smith.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Smith, J.D., Chakrabarti, E. & Levin-Allerhand, J.A. Drug discovery. J Mol Neurosci 24, 145–147 (2004). https://doi.org/10.1385/JMN:24:1:145

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1385/JMN:24:1:145

Index Entries

Search

Navigation