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NAP mechanisms of neuroprotection

  • Neuroprotection
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Abstract

An 8-amino-acid peptide, NAPVSIPQ (NAP), was identified as the smallest active element of activity-dependent neuroprotective protein that exhibits potent neuroprotective action. Potential signal transduction pathways include cGMP production and interference with inflammatory mechanisms, tumor necrosis factor-α, and MAC1-related changes. Because of its intrinsic structure, NAP might interact with extracellular proteins and also transverse membranes. NAP-associated protection against oxidative stress, glucose deprivation, and apoptotic mechanisms suggests interference with fundamental processes. This paper identifies p53, a key regulator of cellular apoptosis, as an intracellular target for NAP’s activity.

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Authors and Affiliations

  1. Department of Clinical Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel

    Illana Gozes & Ruth A. Steingart

  2. Allon Therapeutics Inc., La Jolla, CA, USA

    Avron D. Spier

Authors
  1. Illana Gozes
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  2. Ruth A. Steingart
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  3. Avron D. Spier
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Correspondence to Illana Gozes.

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Gozes, I., Steingart, R.A. & Spier, A.D. NAP mechanisms of neuroprotection. J Mol Neurosci 24, 67–72 (2004). https://doi.org/10.1385/JMN:24:1:067

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