Abstract
Different studies have attempted to find polymorphisms involved in the serotonergic pathway that could be involved in mood disorders and late-onset Alzheimer’s disease (LOAD) symptoms. Here, we compared the frequency of two polymorphisms: monoamine oxidase A (MAOA) and serotonin transporter in LOAD patients versus controls. No evidence of association was observed when these polymorphisms were compared separately; however, the combination of the MAOA allele 1 + the short allele of 5-HTTLPR + ApoE-ɛ4 was significantly more frequent in patients than in controls. It reinforces the hypothesis that different genes acting together might play a role in AD susceptibility. Based on these data, we suggest replicating these studies in larger samples of LOAD patients belonging to different ethnic groups.
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Nishimura, A.L., Guindalini, C., Oliveira, J.R.M. et al. Monoamine oxidase a polymorphism in brazilian patients. J Mol Neurosci 27, 213–217 (2005). https://doi.org/10.1385/JMN:27:2:213
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DOI: https://doi.org/10.1385/JMN:27:2:213