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Dissecting the humoral immune response to simian immunodeficiency virus

Mechanisms of antibody-mediated virus neutralization

Immunologic Research volume 36, pages 51–60 (2006)Cite this article

Abstract

The ultimate goal of an AIDS vaccine is to elicit potent cellular and humoral immune responses that will result in broadly enduring protective immunity. During the past several years, we have focused on characterizing the quantitative and qualitative properties of the antibody response, principally working to define the mechanism(s) of antibody-mediated neutralization in vitro. We have utilized a panel of monoclonal antibodies generated from monkeys infected with attenuated SIV for more than 8 mo to dissect the early events of virus infection involved in antibody-mediated neutralization. Presented herein are highlights from our studies that have identified potential mechanisms by which antibodies neutralize SIV in vitro.

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Affiliations

  1. Department of Medicine, Infections Diseases Division, University of Pittsburgh School of Medicine, 3550 Terrace Street S867 Scaife Hall, 15261, Pittsburgh, PA

    Jonathan D. Steckbeck & Kelly Stefano Cole PhD

Authors
  1. Jonathan D. Steckbeck
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  2. Kelly Stefano Cole PhD
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Correspondence to Kelly Stefano Cole PhD.

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Steckbeck, J.D., Cole, K.S. Dissecting the humoral immune response to simian immunodeficiency virus. Immunol Res 36, 51–60 (2006). https://doi.org/10.1385/IR:36:1:51

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  • DOI: https://doi.org/10.1385/IR:36:1:51

Key Words

  • Neutralization
  • Antibody
  • Surface plasmon resonance
  • SIV envelope
  • Vaccine