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Dual role of the adaptor protein SLP-65

Organizer of signal transduction and tumor suppressor of Pre-B cell leukemia

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Abstract

B cell development is characterized by a coordinated progression through defined stages that are controlled at several checkpoints. Signals from the pre-B cell receptor (pre-BCR) are essential for regulated transition from the pre-B cell stage. The adaptor protein SLP-65 plays a key role in this signaling pathway. Recent findings indicate an additional function of SLP-64 as a tumor suppressor that regulates pre-B cell proliferation. We will discuss here the potential mechanisms by which SLP-65 controls the pre-B cell checkpoint.

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  1. Max-Planck-Institute for Immunobiology, Stuebeweg 51, 79108, Freiburg, Germany

    Sebastian Herzog, Bettina Storch & Hassan Jumaa

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  1. Sebastian Herzog
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  2. Bettina Storch
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  3. Hassan Jumaa
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Correspondence to Hassan Jumaa.

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These authors contributed equally.

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Herzog, S., Storch, B. & Jumaa, H. Dual role of the adaptor protein SLP-65. Immunol Res 34, 143–155 (2006). https://doi.org/10.1385/IR:34:2:143

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