Immunologic Research

, Volume 32, Issue 1–3, pp 31–43

T-Cell stimulation and regulation: With complements from CD46

  • Claudia Kemper
  • James W. Verbsky
  • Jeffrey D. Price
  • John P. Atkinson


Crosslinking of CD46 and CD3 on naïve human CD4+ T-lymphocytes induces interleukin-10 secretion and granzyme B expression. These highly proliferative T-regulatory type 1-like T-regulatory T-cells (Tregs) can suppress an immune response. We propose that this process is important in the prevention of chronic inflammation such as at epithelial borders and in deactivation of a successful immune response. Relative to the latter, once a complement-fixing polyclonal antibody response has been mounted, in most cases, the pathogen will be rapidly destroyed. At this time, the C3b/C4b-bearing immune complexes could initiate the deactivation arm of an immune response by shutting down immunocompetent cells through CD46-generated T-cells. Herein, we review this pathway for the induction of Tregs, focusing on a role for the complement system and especially signaling through CD46 on human T-cells.

Key Words

CD46 Complement T-regulatory T-cells Immunosuppression Interleukin-10 


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Copyright information

© Humana Press Inc 2005

Authors and Affiliations

  • Claudia Kemper
    • 1
  • James W. Verbsky
    • 2
  • Jeffrey D. Price
    • 3
  • John P. Atkinson
    • 1
  1. 1.Department of MedicineWashington University School of MedicineSt. Louis
  2. 2.Department of Pediatrics, Division of RheumatologyWashington University School of MedicineSt. Louis
  3. 3.Department of Graduate Program in ImmunologyWashington University School of MedicineSt. Louis

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