Abstract
The amino acid motif QKRAA on HLA-DRB1*0401 carries susceptibility to develop rheumatoid arthritis through unknown mechanisms. We identified the orginal functions of this motif. In B-cells, HSP73, the constitutive 70-kDa heat-shock protein (HSP), associates with HLA-DRB1*0401. This interaction causes abnormal trafficking of HLA-DRB1*0401. Indeed, HSP73 targets HLA-DRB1*0401 from endoplasmic reticulum to lysosomes bypassing the normal route through the Golgi apparatus and endosomes. In this article, we propose mechanisms to explain how 70-kDa HSPs might contribute to rheumatoid arthritis.
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Auger, I., Roudier, J. Interaction between HSP73 and HLA-DRB1*0401. Immunol Res 31, 261–266 (2005). https://doi.org/10.1385/IR:31:3:261
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DOI: https://doi.org/10.1385/IR:31:3:261