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TGF-β

How tolerant can it be?

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Abstract

A balance between an adequate immune response to an antigen or pathogen and tolerance is a prerequisite for normal immune homeostasis and the well-being of the host. In this complex self-regulation multiple mechanisms have been implicated as contributing to the immune tolerance network, including apoptosis, anergy, and active suppression. Current excitement focuses on active suppression and new regulatory T cell-mediated pathways of immunosuppression that are being unraveled. Central to several of these pathways is transforming growth factor-β (TGF-β), a potent immunoregulatory cytokine that contributes to the function and generation of regulatory T cells.

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  1. Sharon M. Wahl OIIB, NIDCR

    Present address: Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30 Room 320 30 Convent Dr. MSC 4352, 20892-4352, Bethesda, MD

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  1. Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30 Room 320 30 Convent Dr. MSC 4352, 20892-4352, Bethesda, MD

    Wanjun Chen

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Wahl, S.M., Chen, W. TGF-β. Immunol Res 28, 167–179 (2003). https://doi.org/10.1385/IR:28:3:167

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