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Structure of interleukin-10/interleukin-10R1 complex

A paradigm for class 2 cytokine activation

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Abstract

The class II α-helical cytokine family consists of eleven members including the interferons, interleukin-10 (IL-10) and several newly discovered IL-10 homologs. The molecules display a vast array of biologic activities including the ability to induce an antiviral state, modulate inflammatory responses, and inhibit cell growth. Biologic activity is dependent on cytokine-dependent aggregation of two different cell-surface receptors. The detailed protein-protein interactions that initiate these biologic responses are amenable to study using X-ray crystallographic methods. In this article, I summarize my laboratory's contributions to understanding these recognition processes using IL-10 as the prototypic class II cytokine.

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Authors and Affiliations

  1. Department of Microbiology, University of Alabama at Birmingham, 35294, Birmingham, AL

    Mark R. Walter

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  1. Mark R. Walter
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Correspondence to Mark R. Walter.

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Walter, M.R. Structure of interleukin-10/interleukin-10R1 complex. Immunol Res 26, 303–308 (2002). https://doi.org/10.1385/IR:26:1-3:303

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  • DOI: https://doi.org/10.1385/IR:26:1-3:303

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