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Mast cell regulation via paired immunoglobulin-like receptor PIR-B

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Abstract

Activating (PIR-A) and inhibitory (PIR-B) isoforms of the paired immunoglobulin (Ig)-like receptor family have been evaluated for their modulating potential in mast cell responses to IgE antibody and mast/stem cell growth factor (SCF). Mast cells produce PIR-A and PIR-B, but PIR-B was found to be predominantly expressed on the cell surface, where it wasconstitutively tyrosine phosphorylated and associated with SHP-1 tyrosine phosphatase. Efficient coligation of PIR-B with FceRI inhibited IgE-induced mast cell activation and seroton in release. PIR-B and c-kit (or mast/SCF receptor) coligation also inhibited SCF-induced mast cell responses. The PIR-B inhibitory activity was unimpaired in SHP-1-deficient mast cells, perhaps because of non-SHP-1-binding tyrosine-based inhibitory motif in the cytoplasmic tail of PIR-B. This analysis suggests that PIR-B may serve to control mast cell activity.

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Authors and Affiliations

  1. Division of Developmental and clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, 35294, Birmingham, AL

    Ching-Cheng Chen

  2. Department of Pathology, University of Alabama at Birmingham, 35294, Birmingham, AL

    Dong-Won Kang &  Hiromi Kubagawa

  3. Department of Medicine, Howard Hughes Medical Institute, 35294, Birmingham, AL

    Max D. Cooper

Authors
  1. Ching-Cheng Chen
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  2. Dong-Won Kang
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  3. Max D. Cooper
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  4. Hiromi Kubagawa
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Correspondence to Hiromi Kubagawa.

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Chen, CC., Kang, DW., Cooper, M.D. et al. Mast cell regulation via paired immunoglobulin-like receptor PIR-B. Immunol Res 26, 191–197 (2002). https://doi.org/10.1385/IR:26:1-3:191

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  • DOI: https://doi.org/10.1385/IR:26:1-3:191

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