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Positive and negative roles of CD72 in B cell function

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Abstract

Regulation of B cell activation depends on integration of signals transmitted by the B cell receptor (BCR) and a variety of co-receptors. CD72 is a B cell co-receptor that is expressed in all stages of B cell development except plasma cells. Ligation of CD72 enhances B cell growth and differentiation. Recently, the class IV semaphoring, CD 100, has been identified as the natural ligand for CD72. Cytoplasmic domain of CD72 has been shown to be associated with SHP-1 leading to the proposal that the positive effects of CD72 on B cell response may result from sequestration of negative signals from BCR. However, association of CD72 with Grb2 and/or CD19 suggests that CD72 could transmit positive signals. Based on these data, we propose a dual signaling model of CD72.

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  1. Subbarao Bondada

    Present address: Rin 329A Sander Broou Building Centeron Aging, University of Kentucky, 40536, Lexington, KY

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  1. Department of Microbiology and Immunology, University of Kentucky, Lexington, KY

    Hsin-Jung Wu & Subbarao Bondada

  2. The Sanders Brown Center on Aging, University of Kentucky, Lexington, KY

    Hsin-Jung Wu & Subbarao Bondada

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Wu, HJ., Bondada, S. Positive and negative roles of CD72 in B cell function. Immunol Res 25, 155–166 (2002). https://doi.org/10.1385/IR:25:2:155

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