Abstract
Mucosal tissues including the intestine, lung, reproductive tract, and skin form the major interfaces between the outside and internal milieus. Facing the outside is an epithelial cell layer, the epithelium, built on a vascular connective surface. In addition to performing specialized functions, mucosal tissues are sites where immune, epithelial, and neuronal cell types act in concert to maintain tissue integrity and fightin vading pathogens. This article presents the latest findings from my laboratory describing a novel protective function for the intestinal intraepithelial γδ T cells (γδ intraepithelial lymphocytes).
Similar content being viewed by others
References
Powrie F: T cells in inflammatory boweldisease: protective and pathogenic roles. Immunity 1995;3: 171–174.
Mason D, Powrie F: Control of immune rathology by regulatory T cells. Curr Opin Immunol 1998;10:649–655.
De Winter H, Cheroutre H, Kronenberg M: Mucosal immunity and inflammation. II. The yinandyang of T cells in intestinal inflammation: pathogenic and protective rolesina mouse colitis model. Am J Physiol 1999;276:G1317-G1321.
Elson CO, Sartor RB, Tennyson GS, Riddell RH: Experimental models of inflammatory bowel disease. Gastroenterology 1995:109: 1344–1367.
Boismenu R, Hobbs MV, Boullier S, Havran WL: Molecular and cellular biology of dendritic epidermal T cells. Semin Immunol 1996; 8:323–331.
Takashima A, Bergstresser PR: Cytokine-mediated communication by keratinocytes and Langerhars cells with dendritic epidermal T cells. Semin Immunol 1996;8: 333–339.
Yamamoto M, Fujihashi K, Kawabata K, McGhee JR, Kiyono H: A mucosal intranet: intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes. J Immunol 1998; 160:2188–2196.
Havran WL, Chien Y-H, Allison JP: Recognition of self antigens by skin-derived T cells with invariant gamma/delta antigen receptors. Science 1991;252:1430–1432.
Maeurer MJ, Martin D, Walter W, Liu K, Zitvogel L, Halusczeak K, Rabinowich H, Duquesnoy R, Storkus W, Lotze MT: Human intestinal V δ1+T lymphocytesrec-ognize tumor cells of epithelial origin. J Exp Med 1996;183: 1681–1696.
Catalfamo M, Roura-Mir C-Sospedra M, Aparicio P, Costagliola S, Ludgate M, Pujol-Borrell R, Jaraquemada D. Self-reactive cytotoxic γδ T lymphocytes in Graves' disease specifically recognize thyroid epithelial cells. J Immunol 1996;804–811.
Allison JP, Havran WL: The immunobiology of T cells with invariant γδ-antigen receptors. Annu Rev Immunol 1991;9: 679–705.
Kagnoff MF: Current concepts in mucosal immunity. III. Ontogeny and function of gamma delta T cells in the intestine. Am J Physiol 1998; 274:G455-G458.
Boismenu R, Havran WL: Modulation of epithelial cell growth by intraepithelial γδ T cells. Science 1994;266:1253–1255.
Boismenu R, Feng L, Xia YY, Chang JCC, Havran WL: Chemokine expression by intraepithelial γδ T cells: implications for the recruitment of inflammatory cells to epithelial sites. J Immunol 1996; 157:985–992.
Boismenu R, Havran WL: An innate view of γδ T cells. Curr Opin Immunol 1997;9:57–63.
Boismenu R, Chen Y, Havran WL: The role of intraepithelial γδT cells: a gut-feeling. Microbes Infect 1999;1:235–240
Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA: Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science 1989;245: 752–755.
Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R: Anovel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 1990;98: 694–702.
Cooper HS, Murthy SNS, Shah RS, Sedergran DJ: Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 1993;69:238–249.
Mahler M, Bristol IJ, Leiter EH, Workman AE, Birkenmeier EH, Elson CO, Sundberg JP: Differential susceptibility of inbred mouse strains to dex transulfate sodium-induced colitis. Am J Physiol 1998;274:G544-G551.
Dieleman LA, Pena AS, Meuwissen SG, van Rees EP: Role of animal models for the pathogenesis and treatment of inflammatory bowel disease. Scand J Gastroenterol 1997; (Suppl) 223:99–104.
Chen Y, Fuchs E, Havran WL, Boismenu R: submitted.
King DP, Hyde DM, Jackson KA, Novosad DM, Ellis TN, Putney L, Stovall MY, Van Winkle LS, Beaman BL, Ferrick DA. Cutting edge: protective response to pulmonary injury requires gamma delta T lymphocytes. J Immunol 1999;162:5033–5036.
Giacommelli R, Parzanese I, Frieri G, Passacantando A, Pizzuto F, Pimpo T, Cipriani P, Viscido A, Caprilli R, Tonietti G: Increase of circulating γδ T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease. Clin Exp Immunol 1994;98:83–88.
Soderstrom K, Bucht A, Halapi E, Gronberg A, Magnusson I, Kiessling R: Increased frequency of abnormal γδ T cells in blood of patients with inflammatory bowel diseases. J Immunol 1996;156: 2331–2339.
McVay LD, Li B, Biancaniello R, Creighton MA, Bachwich D, Lichtenstein G, Rombeau JL, Carding SR: Changes in human mucosal γδ T cell repertoire and function associated with the disease process in inflammatory bowel disease. Mol Med 1997; 3:183–203.
Finch PW, Pricolo V, Wu A, Finkelstein SD: Increased expression of keratinocyte growth factor messenger RNA associated with inflammatory bowel disease. Gastroenterology 1996;110:441–451.
Finch PW, Cheng AL: Analysis of the cellular basis of keratinocyte growth factor over expression in inflammatory bowel disease. Gut 1999;45:848–855.
Bajaj-Elliott M, Breese E, Poulsom R, Fairelough PD, Mac-Donald TT: Keratinocyte growth factor in inflammatory bowel disease: increased mRNA transcripts in ulcerative colitis compared with Crohn's disease in biopsies and isolated mucosal myofibro blasts. Am J Pathol 1997;151:1469–1476.
Spinozzi F, Agea E, Bistoni O, Forenza N, Monaco A, Bassotti G, Nicoletti I, Riccardi C, Grignani F, Bertotto A: Increased allergen-specific, steroid-sensitive γδ T cells in bronchoalveolar lavage fluid from patients with asthma. Ann Intern Med 1996;124: 223–227.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Boismenu, R. Function of intestinal γδ T cells. Immunol Res 21, 123–127 (2000). https://doi.org/10.1385/IR:21:2-3:123
Issue Date:
DOI: https://doi.org/10.1385/IR:21:2-3:123