Summary
Background. A 43-yr-old man was admitted to our hospital after sudden onset of epigastric pain. He was diagnosed with acute pancreatitis by clinical, laboratory, and radiographic signs. Examinations for the etiology of acute pancreatitis revealed a duodenal tumor arising at the proximal portion of the descending limb, extending by a long stalk, and coming into contact with Vater’s papilla. The tumor was snare-resected endoscopically. Histological examination showed an early carcinoma. Extra-ampullary carcinoma of the duodenum should be considered an unusual cause of acute pancreatitis secondary to obstruction of the major duodenal papilla. Endoscopic polypectomy is effective because of the difficulty in making a precise diagnosis by endoscopic biopsy.
Similar content being viewed by others
References
Adedeji OA, Trescoli-Serrano C, Garcia-Zarco M. Primary duodenal carcinoma. Postgrad Med J 1995;71:354–358.
Perzin KH, Bridge MF. Adenomas of the small intestine: a clinicopathologic review of 51 cases and a study of their relationship to carcinoma. Cancer 1981;48:799–819.
Kutin ND, Ranson B, Gouge TH, et al. Villous tumors of the duodenum. Ann Surg 1975;181:164–168.
Ohmori K, Kinoshita H, Shiraha Y, et al. Pancreatic duct obstruction by a benign polypoid adenoma of the ampulla of Vater. Am J Surg 1976;132:662–663.
Sobel S, Cooperman A. Villous adenoma of the ampulla of Vater. An unusual cause of biliary colic and obstructive jaundice. Gastroenterology 1978;75:107–109.
White SH, Nazarian NA, Smith AE, et al. Periampullary adenoma causing pancreatitis. Br Med J 1981;283:527.
Reynolds R, Lloyd D, Sweeney J, et al. Villous adenoma of the duodenum presenting as acute pancreatitis. J Clin Gastroenterol 1982;4:533–536.
Berk T, Friedman LS, Goldstein SD, et al. Relapsing acute pancreatitis as the presenting manifestation of an ampullary neoplasm in a patient with familial polyposis coli. Am J Gastroenterol 1985;80:627–629.
Burt RW, Rikkers LF, Gardner EJ, et al. Villous adenoma of the duodenal papilla presenting as necrotizing pancreatitis in a patient with Gardner’s syndrome. Gastroenterology 1987;92:532–535.
Guzzardo G, Kleinman MS, Krackov JH, et al. Recurrent acute pancreatitis caused by ampullary villous adenoma. J Clin Gastroenterol 1990;12:200–202.
Sato T, Konishi K, Kimura H, et al. Necrotizing acute pancreatitis caused by tiny carcinoma in adenoma in Vater’s papilla. Gastrointest Endosc 1999;50:672.
Kinoshita H, Hashimoto M, Sajima S, et al. A case of duodenal papillary carcinoma complicated by repeated acute pancreatitis. Kurume Med J 2000;47:229–233.
Tajiri H, Yoshimori M, Nakamura K, et al. An endoscopic study on elevated lesions of the duodenum: Mainly about malignant tumors of the duodenum. Prog Dig Endosc 1982;20:147–151.
O’Brien MJ, Gibbons D. The adenoma-carcinoma sequence in colorectal neoplasia. Surg Oncol Clin N Am 1996;5:513–530.
Tsuchigame T, Urata J, Matsukawa T, et al. Duodenal adenoma removed by endoscopic polypectomy. Digest Endosc 1995;7:417–421.
Reddy RR, Schuman BM, Priest RJ. Duodenal polyps: diagnosis and management. J Clin Gastroenterol 1981;3:139–145.
Ryan DP, Shapiro RH, Warshaw AL. Villous tumors of the duodenum. Ann Surg 1986;203:301–306.
Steinberg W, Tenner S. Acute pancreatitis. N Engl J Med 1994;330:1198–1210.
Nagatani K, Takekoshi T, Baba Y, et al. Indications for endoscopic treatment of early duodenal cancer: based on cases reported in the literature. Endosc Digest 1993;7:969–976.
Hirasawa R, Iishi H, Tatsuta M, et al. Clinicopathologic features and endoscopic resection of duodenal adenocarcinomas and adenomas with the submucosal saline injection technique. Gastrointest Endosc 1997;46:507–513.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Okamoto, Y., Fujii, M., Tateiwa, S. et al. Pedunculated early carcinoma of supra-ampullary duodenum presenting as acute pancreatitis. Int J Gastrointest Canc 31, 185–189 (2002). https://doi.org/10.1385/IJGC:31:1-3:185
Issue Date:
DOI: https://doi.org/10.1385/IJGC:31:1-3:185