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Prognostic significance of the labeling of Adnab-9 in pancreatic intraductal papillary mucinous neoplasms

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Summary

Background. Pancreatic intraductal papillary mucinous neoplasms (IPMN), morphologically resembling colonic adenomas, often have an indefinable malignant potential. We used a monoclonal antibody (MAb) raised against colonic adenomas, Adnab-9, to identify patients with a better prognosis.

Methods. We assessed Adnab-9-labeled sections of these neoplasms from 50 patients, 13 pancreatic adenocarcinomas, and 32 colonic adenomas using standard immunohistochemical techniques.

Results. 26% of the IPMNs labeled with Adnab-9 as compared to 0% of pancreatic ductal cancers or surrounding benign tissues, (p<0.001) and 53% of adenomas (p<0.025). Labeling in IPMNs was usually seen in the noninvasive epithelium suggesting that Adnab-9 is a premalignant marker in these lesions. Labeling of invasive IPMN’s identified a group of patients with a superior overall survival (p=0.027).

Conclusion. Adnab-9 labeling-characteristics appear similar for both IPMNs and adenomatous polyps, suggesting that they are analogous lesions. Adnab-9 labeling may also be a useful prognostic marker for invasive intraductal papillary mucinous neoplasms.

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References

  1. Ohhashi K, Murakami Y, Takekoshi T, et al. Four cases of “mucin-producing” cancer of the pancreas on specific findings of the papilla of Vater. Prog Dig Endosc 1982;20:348–351. Abstract (in Japanese with English abstract)

    Google Scholar 

  2. Siech M, Tripp K, Schmidt-Rohlfing B, et al. Intraductal papillary mucinous tumor of the pancreas. Am J Surg 1999;177:117–120.

    Article  PubMed  CAS  Google Scholar 

  3. Dugan MC, Sarkar FH. Current concepts in pancreatic cancer: symposium summary. Pancreas 1998;17:325–333.

    Article  PubMed  CAS  Google Scholar 

  4. Navarro F, Michel J, Bauret P, et al. Management of intraductal papillary mucinous tumors of the pancreas. Eur J Surg 1999;165:43–48.

    PubMed  CAS  Google Scholar 

  5. Sho M, Nakajima Y, Kanehiro H, et al. Pattern of recurrence after resection for intraductal papillary mucinous tumors of the pancreas. World J Surg 1998;22:874–878.

    Article  PubMed  CAS  Google Scholar 

  6. Shyr Y-M, Su C-H, Tsay S-H, et al. Mucin-producing neoplasms of the pancreas. Intraductal papillary and mucinous cystic neoplasms. Ann Surg 1996;223:141–146.

    Article  PubMed  CAS  Google Scholar 

  7. Kimura W, Makuuchi M, Kuroda A. Characteristics and treatment of mucin-producing tumor of the pancreas. Hepato-gastroenterology 1998;45:2001–2008.

    PubMed  CAS  Google Scholar 

  8. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759–767.

    Article  PubMed  CAS  Google Scholar 

  9. Payan M-J, Xerri L, Moncada K, et al. Villous adenoma of the main pancreatic duct: a potentially malignant tumor? Am J Gastroenterol 1990;85:459–463.

    PubMed  CAS  Google Scholar 

  10. Hoshi T, Imai M, Ogawa K. Frequent K-ras mutations and absence of p53 mutations in mucin-producing tumors of the pancreas. J Surg Oncol 1994;55:84–91.

    Article  PubMed  CAS  Google Scholar 

  11. Sugiyama M, Atomi Y. Extrapancreatic neoplasms occur with unusual frequency in patients with intraductal papillary mucinous tumors of the pancreas. Am J Gastroenterol 1999;94:470–473.

    Article  PubMed  CAS  Google Scholar 

  12. Tobi M, Maliakkal BJ, Alousi MA, et al. Cellular distribution of a colonic adenoma-associated antigen as defined by monoclonal antibody Adnab-9. Scand J Gastroenterol 1992;27:737–742.

    Article  PubMed  CAS  Google Scholar 

  13. Tobi M, Elitsur Y, Moyer MP, et al. Mucosal origin and shedding of an early colonic tumor marker defined by Adnab-9 monoclonal antibody. Scand J Gastroenterol 1993;28:1025–1034.

    Article  PubMed  CAS  Google Scholar 

  14. Tobi M, Kaila V, Hassan N, et al. Monoclonal antibody Adnab-9 defines a preneoplastic marker in epithelium at risk for adenocarcinoma of the small intestine. Hum Pathol 1999;30:467–473.

    Article  PubMed  CAS  Google Scholar 

  15. Greenlee RT, Taylor M, Bolden S, et al. Cancer Statistics 2000. CA A Can J for Clin 2000;50:7–33.

    Article  CAS  Google Scholar 

  16. Ganz T, Lehrer RI. Defensins. Curr Opin Immunol 1994;6:584–589.

    Article  PubMed  CAS  Google Scholar 

  17. Kaplan E, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457–481.

    Article  Google Scholar 

  18. Compagno J, Oertel JE. Mucinous cystic neoplasms of the pancreas with overt and latent malignancy (cystadenocarcinoma and cystadenoma). A clinicopathologic study of 41 cases. Am J Clin Pathol 1978;69:573–580.

    PubMed  CAS  Google Scholar 

  19. Paal E, Thompson LDR, Przygodzki RM, et al. A clinicopathologic and immunohistochemical study of 22 intraductal papillary mucinous neoplasms of the pancreas, with a review of the literature. Mod Pathol 1999;12:518–528.

    PubMed  CAS  Google Scholar 

  20. Shibata D, Reale MA, Lavin P, et al. The DCC protein and prognosis in colorectal cancer. N Engl J Med 1996;335:1727–1732.

    Article  PubMed  CAS  Google Scholar 

  21. Loftus EV, Olivares-Pakzad BA, Batts KP, et al. Intraductal papillary-mucinous tumors of the pancreas: clinicopathologic features, outcome, and nomenclature. Gastroenterology 1996;110:1909–1918.

    Article  PubMed  Google Scholar 

  22. Bohe M, Lindström C, Ohlsson K. Immunohistochemical demonstration of pancreatic secretory proteins in human Paneth cells. Scand J Gastroenterol 1986;21(Suppl. 126):65–68.

    Article  Google Scholar 

  23. Ho SB, Itzkowitz SH, Friera AM, Jiang S-H, Kim YS. Cell lineage markers in premalignant and malignant colonic mucosa. Gastroenterology 1989;97:392–404.

    PubMed  CAS  Google Scholar 

  24. Nagai E, Ueki T, Chijiiwa K, et al. Intraductal papillary mucinous neoplasms of the pancreas associated with so-called “mucinous ductal ectasia.” Histochemical and immunohistochemical analysis of 29 cases. Am J Surg Pathol 1995;19:576–589.

    Article  PubMed  CAS  Google Scholar 

  25. MacPhee M, Chepenik KP, Liddell RA, et al. The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia. Cell 1995;81:957–966.

    Article  PubMed  CAS  Google Scholar 

  26. Fujii H, Inagaki M, Kasai S, et al. Genetic progression and heterogeneity in intraductal papillary-mucinous neoplasms of the pancreas. Am J Pathol 1997;151:1447–1454.

    PubMed  CAS  Google Scholar 

  27. Sessa F, Solcia E, Capella C, et al. Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients. Virchows Archiv 1994;425:357–367.

    Article  PubMed  CAS  Google Scholar 

  28. Taylor S, Gown A, Traverso LW, et al. k-ras mutation, p53 and c-ERBB2 over-expression in the neoplastic progression of intraductal papillary-mucinous tumors of the pancreas. Gastroenterology 1998;114:G2842:A687.

    Google Scholar 

  29. Volk EE, Goldblum JR, Petras RE, et al.. Management and outcome of patients with invasive carcinoma arising in colorectal polyps. Gastroenterology 1995;109:1801–1807.

    Article  PubMed  CAS  Google Scholar 

  30. Terada T, Ohta T, Kitamura Y, et al. Endocrine cells in intraductal papillary-mucinous neoplasms of the pancreas. A histochemical and immunohistochemical study. Virchows Archiv 1997;431:31–36.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Medicine and Pathology, John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan

    Martin Tobi, James Hatfield, Volkan Adsay, Edgar Ben-Josef & Suzanne Fligiel

  2. Virginia Mason Medical Center, Seattle, Washington

    Katherine Galagan & Richard Kozarek

  3. Asahikawa Medical College, Asahikawa, Japan

    Mitsuhiro Inagaki, Shinichi Kasai, Yoshihiko Tokusashi & Takeshi Obara

  4. Johns Hopkins School of Medicine, Baltimore, Maryland

    Ralph H. Hruban

  5. Montreal General Hospital and McGill Medical School, Montreal, Canada

    John Lough, Alan N. Barkun & Mansour Jabbari

  6. Kaiser Permanente and University of California, Davis, Sacramento, California

    Rafiq Sheikh, Boris Ruebner & Michael J. Lawson

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  1. Martin Tobi
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  2. James Hatfield
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  3. Volkan Adsay
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  4. Katherine Galagan
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  17. Edgar Ben-Josef
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  18. Suzanne Fligiel
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Correspondence to Martin Tobi.

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Tobi, M., Hatfield, J., Adsay, V. et al. Prognostic significance of the labeling of Adnab-9 in pancreatic intraductal papillary mucinous neoplasms. International Journal of Pancreatology 29, 141–150 (2001). https://doi.org/10.1385/IJGC:29:3:141

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  • DOI: https://doi.org/10.1385/IJGC:29:3:141

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