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The pancreas and inflammatory bowel diseases

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Summary

This article reviews the literature and gives an overview on prevalence and possible explanations for pancreatic involvement in inflammatory bowel diseases (IBD). IBD patients have a markedly elevated risk for developing acute pancreatitis as well as pancreatic insuffiency. Multiple potential causes for pancreatitis in IBD patients exist. In the majority of cases acute pancreatitis appears to be related to drug side effects or local structural complications rather than a true extraintestinal manifestation of IBD. Nevertheless, some cases of acute pancreatitis remain unexplained. Prevalence of chronic pancreatitis in IBD patients also seems to be relatively high. However, etiology of pancreatic duct changes and/or the occurrence of exocrine insufficiency remain unclear. In most cases chronic pancreatitis is clinically unapparent, although in some patients it may be accompanied by clinically relevant exocrine insufficiency.

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References

  1. Elson CO, Sartor RB, Tennyson GS, Riddell RH. Experimental models of inflammatory bowel disease. Gastroenterology 1995; 109: 1344–1367.

    Article  PubMed  CAS  Google Scholar 

  2. Lembcke B, Kruis W, Sartor R. Systemic Manifestations of IBD. Kluwer Academic Publishers, 1998.

  3. Seyrig JA, Jian R, Modigliani R, Golfain D, Florent C, Messing B, et al. Idiopathic pancreatitis associated with inflammatory bowel disease. Dig Dis Sci 1985; 30: 1121–1126.

    Article  PubMed  CAS  Google Scholar 

  4. Dobrilla G. Regional enteritis and pancreatitis. Gastroenterology 1972; 63: 713, 714.

    PubMed  CAS  Google Scholar 

  5. Meyers S, Greenspan J, Greenstein AJ, Cohen BA, Janowitz HD. Pancreatitis coincident with Crohn’s ileocolitis. Report of a case and review of the literature. Dis Colon Rectum 1987; 30: 119–122.

    Article  PubMed  CAS  Google Scholar 

  6. Gurian LE, Keeffe EB. Pancreatic insufficiency associated with ulcerative colitis and pericholangitis. Gastroenterology 1982; 82: 581–585.

    PubMed  CAS  Google Scholar 

  7. Rasmussen HH, Fonager K, Sorensen HT, Pedersen L, Dahlerup JF, Steffensen FH. Risk of acute pancreatitis in patients with chronic inflammatory bowel disease. A Danish 16-year nationwide follow-up study. Scand J Gastroenterol 1999; 34: 199–201.

    Article  PubMed  CAS  Google Scholar 

  8. Sorensen VZ, Olsen BG, Binder V. Life prospects and quality of life in patients with Crohn’s disease. Gut 1987; 28: 382–385.

    Article  PubMed  CAS  Google Scholar 

  9. Barbara L, Sama C, Morselli LA, Labate AM, Taroni F, Rusticali AG, et al. A population study on the prevalence of gallstone disease: the Sirmione Study. Hepatology 1987; 7: 913–917.

    Article  PubMed  CAS  Google Scholar 

  10. Lirussi F, Nassuato G, Passera D, et al. Gallstone disease in an elderly population: The Silea study. Eur J Gastroenterol Hepatol 1999; 37: 83,84.

    Google Scholar 

  11. Kangas E, Lehmusto P, Matikainen M. Gallstones in Crohn’s disease. Hepatogastroenterology 1990; 37: 83,84.

    PubMed  CAS  Google Scholar 

  12. Lapidus A, Bangstad M, Astrom M, Muhrbeck O. The prevalence of gallstone disease in a defined cohort of patients with Crohn’s disease [see comments]. Am J Gastroenterol 1999; 94: 1261–1266.

    Article  PubMed  CAS  Google Scholar 

  13. Brink MA, Slors JF, Keulemans YC, Mok KS, De Waart DR, Carey MC, et al. Enterohepatic cycling of bilirubin: a putative mechanism for pigment gallstone formation in ileal Crohn’s disease [see comments]. Gastroenterology 1999; 116: 1420–1427.

    Article  PubMed  CAS  Google Scholar 

  14. Lee SP, Nicholls JF, Park HZ. Biliary sludge as a cause of acute pancreatitis [see comments]. N Engl J Med 1992; 326: 589–593.

    Article  PubMed  CAS  Google Scholar 

  15. Matsumoto T, Matsui T, Iida M, Nunoi K, Fujishima M. Acute pancreatitis as a complication of Crohn’s disease. Am J Gastroenterol 1989; 84: 804–807.

    PubMed  CAS  Google Scholar 

  16. Schmitz MP, Malchow H, Pittner PM. Endoscopic and bioptic study of the upper gastrointestinal tract in Crohn’s disease patients. Pathol Res Pract 1985; 179: 377–387.

    Google Scholar 

  17. Oberhuber G, Hirsch M, Stolte M. High incidence of upper gastrointestinal tract involvement in Crohn’s disease. Virchows Arch 1998; 432: 49–52.

    Article  PubMed  CAS  Google Scholar 

  18. Barthelemy CR. Crohn’s disease of the duodenum with spontaneous reflux into the pancreatic duct. Gastrointest Radiol 1983; 8: 319,320.

    Article  PubMed  CAS  Google Scholar 

  19. Meltzer SJ, Korelitz BI. Pancreatitis and duodenopancreatic reflux in Crohn’s disease. Case report and review of the literature. J Clin Gastroenterol 1988; 10: 555–558.

    Article  PubMed  CAS  Google Scholar 

  20. Legge DA, Carlson HC, Hoffman HN. A roentgenologic sign of regional enteritis of the duodenum. Radiology 1971; 100: 37–39.

    PubMed  CAS  Google Scholar 

  21. Altman HS, Phillips G, Bank S, Klotz H. Pancreatitis associated with duodenal Crohn’s disease. Am J Gastroenterol 1983; 78: 174–177.

    PubMed  CAS  Google Scholar 

  22. Eisner TD, Goldman IS, McKinley MJ. Crohn’s disease and pancreatitis. Am J Gastroenterol 1993; 88: 583–586.

    PubMed  CAS  Google Scholar 

  23. Klein S, Greenstein AJ, Sachar DB. Duodenal fistulas in Crohn’s disease. J Clin Gastroenterol 1987; 9: 46–49.

    Article  PubMed  CAS  Google Scholar 

  24. Simmonds SD, Pitman RG, Machan L, Halparin LS. Duodenopancreatic fistula accompanying Crohn’s disease of the distal duodenum. Am J Gastroenterol 1989; 84: 800–803.

    PubMed  CAS  Google Scholar 

  25. Newman LH, Wellinger JR, Present DH, Aufses AH Jr. Crohn’s disease of the duodenum associated with pancreatitis: a case report and review of the literature. Mt Sinai J Med 1987; 54: 429–432.

    PubMed  CAS  Google Scholar 

  26. Schrumpf E, Fausa O, Kolmannskog F, Elgjo K, Ritland S, Gjone E. Sclerosing cholangitis in ulcerative colitis. A follow-up study. Scand J Gastroenterol 1982; 17: 33–39.

    Article  PubMed  CAS  Google Scholar 

  27. Rasmussen HH, Fallingborg J, Mortensen PB, Freund L, Tage-Jensen U, Kruse V. Primary sclerosing cholangitis in patients with ulcerative colitis. Scand J Gastroenterol 1992; 27: 732–736.

    Article  PubMed  CAS  Google Scholar 

  28. Borkje B, Vetvik K, Odegaard S, Schrumpf E, Larssen TB, Kolmannskog F. Chronic pancreatitis in patients with sclerosing cholangitis and ulcerative colitis. Scand J Gastroenterol 1985; 20: 539–542.

    Article  PubMed  CAS  Google Scholar 

  29. Epstein O, Chapman RW, Lake BG, Foo AY, Rosalki SB, Sherlock S. The pancreas in primary biliary cirrhosis and primary sclerosing cholangitis. Gastroenterology 1982; 83: 1177–1182.

    PubMed  CAS  Google Scholar 

  30. Kato Y, Morimoto H, Unoura M, Kobayashi K, Hattori N, Nakanuma Y. Primary biliary cirrhosis and chronic pancreatitis in a patient with ulcerative colitis. J Clin Gastroenterol 1985; 7: 425–427.

    Article  PubMed  CAS  Google Scholar 

  31. Schimanski U, Stiehl A, Stremmel W, Theilmann L. Low prevalence of alterations in the pancreatic duct system in patients with primary sclerosing cholangitis. Endoscopy 1996; 28: 346–349.

    Article  PubMed  CAS  Google Scholar 

  32. Pohl R, Junge U. [Primary sclerosing cholangitis with chronic pancreatitis.] Dtsch Med Wochenschr 1997; 122: 778–782.

    Article  PubMed  CAS  Google Scholar 

  33. Kazumori H, Ashizawa N, Moriyama N, Arima N, Hirakawa K, Adachi K, et al. Primary sclerosing pancreatitis and cholangitis. Int J Pancreatol 1998; 24: 123–127.

    PubMed  CAS  Google Scholar 

  34. Lankisch PG, Droge M, Gottesleben F. Drug induced acute pancreatitis: incidence and severity [see comments]. Gut 1995; 37: 565–567.

    Article  PubMed  CAS  Google Scholar 

  35. Hangartner PJ, Buhler H, Munch R, Zaruba K, Stamm B, Ammann R. [Chronic pancreatitis as a possible result of analgesic abuse.] Schweiz Med Wochenschr 1987; 117: 638–642.

    PubMed  CAS  Google Scholar 

  36. Liu BA, Knowles SR, Cohen LB, Werb MR, Shear NH. Pancreatic insufficiency due to antituberculous therapy. Ann Pharmacother 1997; 31: 724–726.

    PubMed  CAS  Google Scholar 

  37. Pezzilli R, Dilli P, Melandri R, Broccoli PL, Fontana G. Anticonvulsant-induced chronic pancreatitis. A case report. Ital J Gastroenterol 1992; 24: 245,246.

    PubMed  CAS  Google Scholar 

  38. Mallory A, Kern F. Drug-induced pancreatitis: a critical review. Gastroenterology 1980; 78: 813–820.

    PubMed  CAS  Google Scholar 

  39. Frick TW, Speiser DE, Bimmler D, Largiader F. Drug-induced acute pancreatitis: further criticism. Dig Dis 1993; 11: 113–132.

    Article  PubMed  CAS  Google Scholar 

  40. Underwood TW, Frye CB. Drug-induced pancreatitis. Clin Pharm 1993; 12: 440–448.

    PubMed  CAS  Google Scholar 

  41. Wilmink T, Frick TW. Drug-induced pancreatitis. Drug Saf 1996; 14: 406–423.

    PubMed  CAS  Google Scholar 

  42. Levine RA, McGuire RF. Corticosteroid-induced pancreatitis: a case report demonstrating recurrence with rechallenge. Am J Gastroenterol 1988; 83: 1161–1164.

    PubMed  CAS  Google Scholar 

  43. Prantera C, Zannoni F, Scribano ML, Berto E, Andreoli A, Kohn A, et al. An antibiotic regimen for the treatment of active Crohn’s disease: a randomized, controlled clinical trial of metronidazole plus ciprofloxacin. Am J Gastroenterol 1996; 91: 328–332.

    PubMed  CAS  Google Scholar 

  44. Celifarco A, Warschauer C, Burakoff R. Metronidazole-induced pancreatitis. Am J Gastroenterol 1989; 84: 958–960.

    PubMed  CAS  Google Scholar 

  45. Friedman GD, Selby JV. How often does metronidazole induce pancreatitis? Gastroenterology 1990; 98: 1702,1703.

    PubMed  CAS  Google Scholar 

  46. Corey WA, Doebbeling BN, DeJong KJ, Britigan BE. Metronidazole-induced acute pancreatitis [see comments]. Rev Infect Dis 1991; 13: 1213–1215.

    PubMed  CAS  Google Scholar 

  47. Plotnick BH, Cohen I, Tsang T, Cullinane T. Metronidazole-induced pancreatitis. Ann Intern Med 1985; 103: 891,892.

    PubMed  CAS  Google Scholar 

  48. Sanford KA, Mayle JE, Dean HA, Greenbaum DS. Metronidazole-associated pancreatitis. Ann Intern Med 1988; 109: 756,757.

    PubMed  CAS  Google Scholar 

  49. de-Jongh FE, Ottervanger JP, Stuiver PC. [Acute pancreatitis caused by metronidazole.] Ned Tijdschr Geneeskd 1996; 140: 37,38.

    PubMed  CAS  Google Scholar 

  50. Prantera C, Cottone M, Pallone F, Annese V, Franze A, Cerutti R, et al. Mesalamine in the treatment of mild to moderate active Crohn’s ileitis: results of a randomized, multicenter trial. Gastroenterology 1999; 116: 521–526.

    Article  PubMed  CAS  Google Scholar 

  51. Schreiber S, Howaldt S, Raedler A. Oral 4-aminosalicylic acid versus 5-aminosalicylic acid slow release tablets. Double blind, controlled pilot study in the maintenance treatment of Crohn’s ileocolitis. Gut 1994; 35: 1081–1085.

    Article  PubMed  CAS  Google Scholar 

  52. Courtney MG, Nunes DP, Bergin CF, O’Driscoll M, Trimble V, Keeling PW, et al. Randomised comparison of olsalazine and mesalazine in prevention of relapses in ulcerative colitis [see comments]. Lancet 1992; 339: 1279–1281.

    Article  PubMed  CAS  Google Scholar 

  53. Zinberg J, Molinas S, Das KM. Double-blind Placebocontrolled study of olsalazine in the treatment of ulcerative colitis. Am J Gastroenterol 1990; 85: 562–566.

    PubMed  CAS  Google Scholar 

  54. Block MB, Genant HK, Kirsner JB. Pancreatitis as an adverse reaction to salicylazosulfapyridine. N Engl J Med 1970; 282: 380–382.

    Article  PubMed  CAS  Google Scholar 

  55. Marteau P, Nelet F, Le-Lu M, Devaux C. Adverse events in patients treated with 5-aminosalicyclic acid: 1993–1994 pharmacovigilance report for Pentasa in France. Aliment Pharmacol Ther 1996; 10: 949–956.

    Article  PubMed  CAS  Google Scholar 

  56. Deprez P, Descamps C, Fiasse R. Pancreatitis induced by 5-aminosalicylic acid [letter]. Lancet 1989; 2: 445,446.

    Article  PubMed  CAS  Google Scholar 

  57. Fernandez J, Sala M, Panes J, Feu F, Navarro S, Teres J. Acute pancreatitis after long-term 5-aminosalicylic acid therapy. Am J Gastroenterol 1997; 92: 2302,2303.

    PubMed  CAS  Google Scholar 

  58. Goebell H, Dignass A. Chronic IBD and the pancreas, in Systemic Manifestations of IBD, Lembcke, B., Kruis W., Sartor, R. B., eds. Kluwer Academic Publishers, Dordrecht, The Netherlands, 1998; pp. 143–148.

    Google Scholar 

  59. Isaacs KL, Murphy D. Pancreatitis after rectal administration of 5-aminosalicylic acid. J Clin Gastroenterol 1990; 12: 198,199.

    Article  PubMed  CAS  Google Scholar 

  60. Sandborn WJ. Azathioprine: state of the art in inflammatory bowel disease. Scand J Gastroenterol Suppl 1998; 225: 92–99.

    Article  PubMed  CAS  Google Scholar 

  61. Present DH, Meltzer SJ, Krumholz MP, Wolke A, Korelitz BI. 6-Mercaptoprurine in the management of inflammatory bowel disease: short- and long-term toxicity. Ann Intern Med 1989; 111: 641–649.

    PubMed  CAS  Google Scholar 

  62. Cohen RD, Stein R, Hanauer SB. Intravenous cyclosporin in ulcerative colitis: a five-year experience. Am J Gastroenterol 1999; 94: 1587–1592.

    Article  PubMed  CAS  Google Scholar 

  63. Fellermann K, Ludwig D, Stahl M, David WT, Stange EF. Steroid-unresponsive acute attacks of inflammatory bowel disease: immunomodulation by tacrolimus (FK506). Am J Gastroenterol 1998; 93: 1860–1866.

    Article  PubMed  CAS  Google Scholar 

  64. Runzi M, Layer P. Drug-associated pancreatitis: facts and fiction [see comments]. Pancreas 1996; 13: 100–109.

    Article  PubMed  CAS  Google Scholar 

  65. Katz S, Bank S, Greenberg RE, Lendvai S, Lesser M, Napolitano B. Hyperamylasemia in inflammatory bowel disease. J Clin Gastroenterol 1988; 10: 627–630.

    Article  PubMed  CAS  Google Scholar 

  66. Tromm A, Holtmann B, Huppe D, Kuntz HD, Schwegler U, May B. [Hyperamylasemia, hyperlipasemia and acute pancreatitis in chronic inflammatory bowel diseases]. Leber Magen Darm 1991; 21: 15–22.

    PubMed  CAS  Google Scholar 

  67. Keikius B, Niemela S, Lehtola J, Karttunen TJ. Elevated pancreatic enzymes in inflammatory bowel disease are associated with extensive disease. Am J Gastroenterol 1999; 94: 1062–1069.

    Article  Google Scholar 

  68. Stocker W, Otte M, Ulrich S, Normann D, Finkbeiner H, Stocker K, et al. Autoimmunity to pancreatic juice in Crohn’s disease. Results of an autoantibody screening in patients with chronic inflammatory bowel disease. Scand J Gastroenterol Suppl 1987; 139: 41–52.

    Article  PubMed  CAS  Google Scholar 

  69. Seibold F, Weber P, Jenss H, Wiedmann KH. Antibodies to a trypsin sensitive pancreatic antigen in chronic inflammatory bowel disease: specific markers for a subgroup of patients with Crohn’s disease. Gut 1991; 32: 1192–1197.

    Article  PubMed  CAS  Google Scholar 

  70. Weber P, Seibold F, Jenss H. Acute pancreatitis in Crohn’s disease [see comments]. J Clin Gastroenterol 1993; 17: 286–291.

    Article  PubMed  CAS  Google Scholar 

  71. Seibold F, Scheurlen M, Muller A, Jenss H, Weber P. Impaired pancreatic function in patients with Crohn’s disease with and without pancreatic autoantibodies. J Clin Gastroenterol 1996; 22: 202–206.

    Article  PubMed  CAS  Google Scholar 

  72. Glaser J. [Imaging diagnosis of diseases of the pancreas.] Dtsch Med Wochenschr 1990; 115: 1361–1367.

    Article  PubMed  CAS  Google Scholar 

  73. Axon AT, Ashton MG, Lintott DJ. Chronic pancreatitis and inflammatory bowel disease. Clin Radiol 1979; 30: 179–182.

    Article  PubMed  CAS  Google Scholar 

  74. Heikius B, Niemela S, Lehtola J, Karttunen T, Lahde S. Pancreatic duct abnormalities and pancreatic function in patients with chronic inflammatory bowel disease. Scand J Gastroenterol 1996; 31: 517–523.

    Article  PubMed  CAS  Google Scholar 

  75. Braganza JM, Hunt LP, Warwick F. Relationship between pancreatic exocrine function and ductal morphology in chronic pancreatitis. Gastroenterology 1982; 82: 1341–1347.

    PubMed  CAS  Google Scholar 

  76. Angelini G, Cavallini G, Bovo P, et al. Pancreatic function in chronic inflammatory bowel disease. Int J Pancreatol 1988; 3: 185–193.

    PubMed  CAS  Google Scholar 

  77. Hegnhoj J, Hansen CP, Rannem T, Sobirk H, Andersen LB, Andersen JR. Pancreatic function in Crohn’s disease. Gut 1990; 31: 1076–1079.

    Article  PubMed  CAS  Google Scholar 

  78. Gschwantler M, Kogelbauer G, Klose W, Bibus B, Tscholakoff D, Weiss W. The pancreas as a site of granulomatous inflammation in Crohn’s disease [see comments]. Gastroenterology 1995; 108: 1246–1249.

    Article  PubMed  CAS  Google Scholar 

  79. Ball W, Baggenstoss A, Bargen J. Pancreatic lesions associated with chronic ulcerative colitis. Arch Pathol 1950; 50: 347–358.

    CAS  Google Scholar 

  80. Chapin L, Scudamore H, Baggenstoss A, Bargen J. Regional enteritis associated with visceral changes. Gastroenterology 1956; 30: 404–415.

    PubMed  CAS  Google Scholar 

  81. Takizawa H, Natsui M, Aoyagi Y, Asakura H. Pancreatitis in ulcerative colitis: a case report of improved stricuture of the main pancreatic duct. J Clin Gastroenterol 1999; 28: 74–76.

    Article  PubMed  CAS  Google Scholar 

  82. Keljo DJ, Sugerman KS. Pancreatitis in patients with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 1997; 25: 108–112.

    Article  PubMed  CAS  Google Scholar 

  83. Castiella A, Lopez P, Bujanda L, et al. Ulcerative colitis associated with acute pancreatitis and platelet aggregates. J Clin Gastroenterol 1996; 23: 77,78.

    Article  PubMed  CAS  Google Scholar 

  84. Ohishi T, Serizawa H, Hamada Y, et al. [A case of chronic continuous ulcerative colitis associated with acute pancreatitis]. Nippon Shokakibyo Gakkai Zasshi 1995; 92: 984–990.

    PubMed  CAS  Google Scholar 

  85. Bauer W, Tepper R, Katz S. Megacolon as a presenting finding of acute pancreatitis associated with chronic ulcerative colitis: unusual presentation of an unusual association. Am J Gastroenterol 1995; 90: 1013–1015.

    PubMed  CAS  Google Scholar 

  86. Omata F, Arakawa S, Takahashi H, Ueno F. Crohn’s disease associated with pancreatitis of unknown etiology: a case report. Gastroenterol Jpn 1993; 28: 420–423.

    PubMed  CAS  Google Scholar 

  87. Niemela S, Lehtola J, Karttunen T, Lahde S. Pancreatitis in patients with chronic inflammatory bowel disease [see comments]. Hepatogastroenterology. 1989; 36: 175–177.

    PubMed  CAS  Google Scholar 

  88. Seidman EG, Deckelbaum RJ, Owen H, de Chadarevian JP, Weber AM, Morin CL. Relapsing pancreatitis in association with Crohn’s disease. J Pediatr Gastroenterol Nutr 1983; 2: 178–182.

    Article  PubMed  CAS  Google Scholar 

  89. Malka D, Levy P, Chemtob A, Bernades P. [Acute relapsing pancreatitis, revealing Crohn disease, and regressing under corticotherapy.] Gastroenterol Clin Biol 1994; 18: 892–894.

    PubMed  CAS  Google Scholar 

  90. Lysy J, Goldin E. Pancreatitis in ulcerative colitis. J Clin Gastroenterol 1992; 15: 336–339.

    Article  PubMed  CAS  Google Scholar 

  91. Forbes D, Scott RB, Trevenen C, Hershfield N, Gall DG. Chronic pancreatitis associated with ulcerative colitis. Clin Invest Med 1987; 10: 321–324.

    PubMed  CAS  Google Scholar 

  92. Okumura Y, Tamba J, Shintani Y, Yoshioka U, Inoue H, Fujiyama Y, et al. Macrolipasemia in Crohn’s disease. Pancreas 1998; 16: 205–210.

    Article  PubMed  CAS  Google Scholar 

  93. Ectors N, Maillet B, Aerts R, Gebols K, Donner A, Borchard F, et al. Non-alcoholic duct destructive chronic pancreatitis [see comments]. Gut 1997; 41: 263–268.

    Article  PubMed  CAS  Google Scholar 

  94. Ahmad M, Bauer W, Katz S. Ulcerative colitis, hyperamylasemia, and asymptomatic pancreatic calcifications: making the case for pancreatitis as an extra luminal manifestation. Am J Gastroenterol 1997; 92: 2307–2309.

    PubMed  CAS  Google Scholar 

  95. Tromm A, Huppe D, Micklefield GH, Schwegler U, May B. Acute pancreatitis complicating Crohn’s disease: mere coincidence or causality? Gut 1992; 33: 1289–1291.

    Article  PubMed  CAS  Google Scholar 

  96. Heikius B, Niemela S, Lehtola J, Karttunen T, Lahde S. Hepatobiliary and coexisting pancreatic duct abnormalities in patients with inflammatory bowel disease. Scand J Gastroenterol 1997; 32: 153–161.

    Article  PubMed  CAS  Google Scholar 

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  1. Division of Gastroenterology, Department of Internal Medicine I, Medical University of Luebeck, Ratzeburger Alee 160, 23538, Luebeck, Germany

    Klaus R. Herrlinger & Eduard F. Stange

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Herrlinger, K.R., Stange, E.F. The pancreas and inflammatory bowel diseases. International Journal of Pancreatology 27, 171–179 (2000). https://doi.org/10.1385/IJGC:27:3:171

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