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International Journal of Pancreatology

, Volume 29, Issue 3, pp 141–150 | Cite as

Prognostic significance of the labeling of Adnab-9 in pancreatic intraductal papillary mucinous neoplasms

  • Martin TobiEmail author
  • James Hatfield
  • Volkan Adsay
  • Katherine Galagan
  • Richard Kozarek
  • Mitsuhiro Inagaki
  • Shinichi Kasai
  • Yoshihiko Tokusashi
  • Takeshi Obara
  • Ralph H. Hruban
  • John Lough
  • Alan N. Barkun
  • Mansour Jabbari
  • Rafiq Sheikh
  • Boris Ruebner
  • Michael J. Lawson
  • Edgar Ben-Josef
  • Suzanne Fligiel
Article

Summary

Background. Pancreatic intraductal papillary mucinous neoplasms (IPMN), morphologically resembling colonic adenomas, often have an indefinable malignant potential. We used a monoclonal antibody (MAb) raised against colonic adenomas, Adnab-9, to identify patients with a better prognosis.

Methods. We assessed Adnab-9-labeled sections of these neoplasms from 50 patients, 13 pancreatic adenocarcinomas, and 32 colonic adenomas using standard immunohistochemical techniques.

Results. 26% of the IPMNs labeled with Adnab-9 as compared to 0% of pancreatic ductal cancers or surrounding benign tissues, (p<0.001) and 53% of adenomas (p<0.025). Labeling in IPMNs was usually seen in the noninvasive epithelium suggesting that Adnab-9 is a premalignant marker in these lesions. Labeling of invasive IPMN’s identified a group of patients with a superior overall survival (p=0.027).

Conclusion. Adnab-9 labeling-characteristics appear similar for both IPMNs and adenomatous polyps, suggesting that they are analogous lesions. Adnab-9 labeling may also be a useful prognostic marker for invasive intraductal papillary mucinous neoplasms.

Key Words

colorectal cancer immunostaining intraductal papillary mucinous neoplasms monoclonal antibody pancreatic ductal cancer severely dysplastic adenomatous colonic polyps 

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Copyright information

© Humana Press Inc. 2002

Authors and Affiliations

  • Martin Tobi
    • 1
    Email author
  • James Hatfield
    • 1
  • Volkan Adsay
    • 1
  • Katherine Galagan
    • 2
  • Richard Kozarek
    • 2
  • Mitsuhiro Inagaki
    • 3
  • Shinichi Kasai
    • 3
  • Yoshihiko Tokusashi
    • 3
  • Takeshi Obara
    • 3
  • Ralph H. Hruban
    • 4
  • John Lough
    • 5
  • Alan N. Barkun
    • 5
  • Mansour Jabbari
    • 5
  • Rafiq Sheikh
    • 6
  • Boris Ruebner
    • 6
  • Michael J. Lawson
    • 6
  • Edgar Ben-Josef
    • 1
  • Suzanne Fligiel
    • 1
  1. 1.Departments of Medicine and PathologyJohn D. Dingell Veterans Affairs Medical CenterDetroit
  2. 2.Virginia Mason Medical CenterSeattle
  3. 3.Asahikawa Medical CollegeAsahikawaJapan
  4. 4.Johns Hopkins School of MedicineBaltimore
  5. 5.Montreal General Hospital and McGill Medical SchoolMontrealCanada
  6. 6.Kaiser Permanente and University of CaliforniaDavis, Sacramento

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