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Combined sellar fibrosarcoma and prolactinoma with neuronal metaplasia: Report of a case unassociated with radiotherapy

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Abstract

We report the occurrence of a primary pituitary fibrosarcoma causally unrelated to radiotherapy, admixed in association with a prolactin cell pituitary adenoma showing neuronal metaplasia. These unique findings were associated with multiple endocrine neoplasia type 1 (MEN 1).

Primary fibrosarcoma involving the sella is a very rare tumor. The majority of cases have been associated with prior irradiation of either a pituitary adenoma or a craniopharyngioma. Pituitary adenoma with neuronal metaplasia is also rare and usually occurs in the setting of acromegaly. Despite the intimate association of both elements in our lesion, no transition of adenoma to sarcoma was demonstrable by immunohistochemistry or in situ hybridization studies.

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Authors and Affiliations

  1. Department of Pathology, Mayo Clinic, Rochester, MN

    Mario Moro, Caterina Giannini,  Bernd W. Scheithauer & Ricardo V. Lloyd

  2. Department of Pathology, Auckland Hospital, Auckland, New Zealand

    Paul Restall

  3. Department of Endocrinology, Auckland Hospital, Auckland, New Zealand

    Carl Eagleton

  4. Department of Neurosurgery, Auckland Hospital, Auckland, New Zealand

    Andrew J. Law

  5. St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada

    Kalman Kovacs

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  1. Mario Moro
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Correspondence to Bernd W. Scheithauer.

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Moro, M., Giannini, C., Scheithauer, B.W. et al. Combined sellar fibrosarcoma and prolactinoma with neuronal metaplasia: Report of a case unassociated with radiotherapy. Endocr Pathol 15, 149–158 (2004). https://doi.org/10.1385/EP:15:2:149

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