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Combined “mixed medullary-follicular” and “papillary” carcinoma of the thyroid with lymph node metastasis

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Abstract

We report a case of combined “mixed medullary-follicular” and “papillary” carcinoma of the thyroid that occurred in a 44-yr-old Japanese woman. The grossly single 3 cm tumor was histologically composed of both mixed medullary-follicular carcinoma and papillary carcinoma, which abutted against each other with a clear border between two components. Immunohistochemically, the component of medullary carcinoma was positive for calcitonin and carcinomebryonic antigen (CEA), and the follicular carcinoma and papillary carcinoma components were positive for thyroglobulin. Lymph node metastasis was also noted. The patient has been alive without recurrence for 20 yr. To the best of our knowledge, this is the first reported case in the literature. We report this unique case of thyroid carcinoma and review related thyroid malignancies.

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Authors and Affiliations

  1. First Department of Pathology, School of Medicine, University of Tokushima, Tokushima

    Mitsuyoshi Hirokawa MD

  2. Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, PA

    Virginia A. LiVolsi MD

  3. School of Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa

    Yuji Mizukami MD

  4. Kawasaki College of Allied Health Professions, Kurashiki

    Tanekazu Harada MD

  5. Department of Pathology, Kawasaki Medical School, Kurashiki

    Toshiaki Manabe MD

  6. Department of Surgical Pathology, Hokkaido University Hospital, North 14, West 5, Kita-ku, 060-8648, Sapporo, Japan

    Michio Shimizu MD & Tomoo Itoh MD

Authors
  1. Michio Shimizu MD
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  2. Mitsuyoshi Hirokawa MD
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  3. Virginia A. LiVolsi MD
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  4. Yuji Mizukami MD
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  5. Tanekazu Harada MD
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  6. Tomoo Itoh MD
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  7. Toshiaki Manabe MD
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Corresponding author

Correspondence to Michio Shimizu MD.

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Shimizu, M., Hirokawa, M., LiVolsi, V.A. et al. Combined “mixed medullary-follicular” and “papillary” carcinoma of the thyroid with lymph node metastasis. Endocr Pathol 11, 353–358 (2000). https://doi.org/10.1385/EP:11:4:353

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  • DOI: https://doi.org/10.1385/EP:11:4:353

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