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The Pro12Ala polymorphism of the PPAR gamma 2 gene influences sex hormone-binding globulin level and its relationship to the development of the metabolic syndrome in young finnish men

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Abstract

Assocation of low sex hormone-binding globulin (SHBG) level with the risk of the metabolic syndrome (MetS) in men has previously been reported. A proline to alanine substitution in codon 12 of the peroxisome proliferator activated receptor gamma 2 (PPARγ2) gene has been shown to be related to high insulin sensitivity. The relationship of SHBG levels with the Pro12Ala polymorphism of PPARγ2 in men has not been previously studied. Therefore, we investigated the effect of the Pro12Ala polymorphism of PPARγ2 on SHBG levels in 202 young Finnish men. The range of SHBG was from 3.30 to 73 nmol/L (geometric mean=17.90; 95% Cl=16.62–19.25 nmol/L). Baseline SHBG levels tended to be lower in men who developed the MetS (n=11) compared to men who did not develop the MetS (n=169) (22.85 vs 17.26 nmol/L) on a high-caloric diet during their 6 mo military service. SHBG levels tended to be higher among the subjects with the Al12Ala genotype compared to subjects with the Pro12Pro or Pro12Ala genotypes of the PPARγ gene (27.7 vs 21.7 and 22.7 nmol/L). Among the carriers of the Pro12Pro genotype, those who developed the MetS (n=8) had significantly lower levels of SHBG compared to men who did not develop the MetS (n=93) (13.23 vs 24.22 nmol/L, p=0.027). Among the subjects who developed the MetS those with the Pro12Pro genotype (n=3) had significantly lower levels of SHBG compared to subjects with X12Ala (n=8) (13.23 vs 28 nmol/L, p=0.025). We conclude that the 12Ala allele of PPARγ2, may influence SHBG levels in young Finnish men.

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Authors and Affiliations

  1. Unit of General Practice, Central University Hospital of Oulu, Finland

    Firoozeh Mousavinasab MD, Jari Jokelainen & Sirkka Keinänen-Kiukaanniemi

  2. Health Centre of Haukipudas, Finland

    Tuula Tähtinen

  3. Health Centre of Laukaa, Finland

    Mauno Vanhala

  4. National Public Health Institute, Oulu, Finland

    Pentti Koskela

  5. Army Health Centre, Parolannummi, Finland

    Jorma Oikarinen

  6. Department of Medicine, University of Kuopio, Finland

    Markku Laakso

  7. Health Centre of Oulu, Finland

    Sirkka Keinänen-Kiukaanniemi

  8. Department of Public Health Science and General Practice, University of Oulu, A apistie 1, P.O. Box 5000, 90014, Fin, Finland

    Firoozeh Mousavinasab MD, Jari Jokelainen & Sirkka Keinänen-Kiukaanniemi

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  1. Firoozeh Mousavinasab MD
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  2. Tuula Tähtinen
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Correspondence to Firoozeh Mousavinasab MD.

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Mousavinasab, F., Tähtinen, T., Jokelainen, J. et al. The Pro12Ala polymorphism of the PPAR gamma 2 gene influences sex hormone-binding globulin level and its relationship to the development of the metabolic syndrome in young finnish men. Endocr 30, 185–190 (2006). https://doi.org/10.1385/ENDO:30:2:185

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  • DOI: https://doi.org/10.1385/ENDO:30:2:185

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