Skip to main content
SpringerLink
Log in

PYY in the expanding pancreatic epithelium

  • Original Articles
  • Published:
Endocrine Aims and scope Submit manuscript

Abstract

Gut peptide YY (PYY) plays an important role in regulating metabolism and is expressed during the ontogeny of the pancreas. However, its biological role during endocrine cell formation is not fully understood, and its role, if any, during pancreatic regeneration in the adult has not yet been explored. The knowledge of factors involved in beta cell renewal in adult animals is clearly relevant for the design of treatment strategies for type 1 diabetes. We therefore sought to determine if observations during fetal pancreas formation also apply to pancreatic growth in adult animals. Indeed, we have found marked expansion of the PYY-expressing population during pancreatic regeneration. In addition, we demonstrate the presence of cells co-expressing PYY and the critical pancreatic transcription factor pancreatic duodenal homeobox 1 (PDX-1). Interestingly, these cells also co-expressed specific islet hormones during pancreatic development and re-growth, suggesting a developmental relationship. Furthermore, we have found that PYY can act in concert with IGF-1 to stimulate cellular responsiveness in pancreatic epithelial cells in vitro. Our data suggest that PYY may be a mediator of islet cell development, as well as a cofactor for growth factor responses, not only during fetal pancreas formation but also during regeneration in adult animals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Edlund, H. (2002). Nat. Rev. Genet. 3, 524–532.

    Article  PubMed  CAS  Google Scholar 

  2. Anderle, P., Langguth, P., Rubas, W., and Merkle, H. P. (2002). J. Pharm. Sci. 91, 290–300.

    Article  PubMed  CAS  Google Scholar 

  3. Apelqvist, A., Ahlgren, U., and Edlund, H. (1997). Curr. Biol. 7, 801–804.

    Article  PubMed  CAS  Google Scholar 

  4. Duncan, S. A., Manova, K., Chen, W. S., et al. (1994). Proc. Natl. Acad. Sci. USA 91, 7598–7602.

    Article  PubMed  CAS  Google Scholar 

  5. Guz, Y., Montminy, M. R., Stein, R., et al. (1995). Development 121, 11–18.

    PubMed  CAS  Google Scholar 

  6. Howarth, G. S. and Shoubridge, C. A. (2001). Curr. Opin. Pharmacol. 1, 568–74.

    Article  PubMed  CAS  Google Scholar 

  7. Kim, S. K. and Hebrok, M. (2001). Genes Dev. 15, 111–127.

    Article  PubMed  CAS  Google Scholar 

  8. Larsson, L. I., Madsen, O. D., Serup, P., Jonsson, J., and Edlund, H. (1996). Mech. Dev. 60, 175–184.

    Article  PubMed  CAS  Google Scholar 

  9. Lee, C. S., Perreault, N., Brestelli, J. E., and Kaestner, K. H. (2002). Genes Dev. 16, 1488–1497.

    Article  PubMed  CAS  Google Scholar 

  10. Polk, D. B. and Tong, W. (1999). Am. J. Physiol. 277(6 Pt 1), C1149–1159.

    PubMed  CAS  Google Scholar 

  11. Rausa, F. M., Galarneau, L., Belanger, L., and Costa, R. H. (1999). Mech. Dev. 89, 185–188.

    Article  PubMed  CAS  Google Scholar 

  12. Yamaoka, T. and Itakura, M. (1999). Int. J. Mol. Med. 3, 247–261.

    PubMed  CAS  Google Scholar 

  13. Kawaguchi, Y., Cooper, B., Gannon, M., Ray, M., MacDonald, R. J., and Wright, C. V. (2002). Nat. Genet. 32, 128–134.

    Article  PubMed  CAS  Google Scholar 

  14. Suzuki, A., Nakauchi, H., and Taniguchi, H. (2003). Proc. Natl. Acad. Sci. USA 100, 5034–5039.

    Article  PubMed  CAS  Google Scholar 

  15. Batterham, R. L. and Bloom, S. R. (2003). Ann. NY Acad. Sci. 994, 162–168.

    Article  PubMed  CAS  Google Scholar 

  16. Batterham, R. L., Le Roux, C. W., Cohen, M. A., et al. (2003). J. Clin. Endocrinol. Metab. 88, 3989–3992.

    Article  PubMed  CAS  Google Scholar 

  17. Batterham, R. L., Cohen, M. A., Ellis, S. M., et al. (2003). N. Engl. J. Med. 349, 941–948.

    Article  PubMed  CAS  Google Scholar 

  18. van den Hoek, A. M., Heijboer, A. C., Corssmit, E. P., et al. (2004). Diabetes 53, 1949–1952.

    Article  PubMed  Google Scholar 

  19. Upchurch, B. H., Fung, B. P., Rindi, G., Ronco, A., and Leiter, A. B. (1996). Development 122, 1157–1163.

    PubMed  CAS  Google Scholar 

  20. Upchurch, B. H., Aponte, G. W., and Leiter, A. B. (1994). Development 120, 245–252.

    PubMed  CAS  Google Scholar 

  21. Gu, D. and Sarvetnick, N. (1993). Development 118, 33–46.

    PubMed  CAS  Google Scholar 

  22. Gu, D. and Sarvetnick, N. (1994). Recent Prog. Horm. Res. 49, 161–165.

    PubMed  CAS  Google Scholar 

  23. Sarvetnick, N., Shizuru, J., Liggitt, D., et al. (1990). Nature 346, 844–847.

    Article  PubMed  CAS  Google Scholar 

  24. Myrsen-Axcrona, U., Ekblad, E., and Sundler, F. (1997). Regul. Pept. 68, 165–175.

    Article  PubMed  CAS  Google Scholar 

  25. Sandstrom, O. and El-Salhy, M. (2002). Peptides 23, 263–267.

    Article  PubMed  CAS  Google Scholar 

  26. Jackerott, M. and Larsson, L. I. (1997). J. Histochem. Cytochem. 45, 1643–1650.

    PubMed  CAS  Google Scholar 

  27. Mannon, P. J. (2002). Peptides 23, 383–88.

    Article  PubMed  CAS  Google Scholar 

  28. Mannon, P. J. and Mele, J. M. (2000). Biochem. J. 350, 655–661.

    Article  PubMed  CAS  Google Scholar 

  29. Leiter, E. H., Malinoski, F. J., and Eppig, J. J. (1978). Cancer Res. 38, 969–977.

    PubMed  CAS  Google Scholar 

  30. Jonsson, J., Carlsson, L., Edlund, T., and Edlund, H. (1994). Nature 371, 606–609.

    Article  PubMed  CAS  Google Scholar 

  31. Offield, M. F., Jetton, T. L., Labosky, P. A., et al. (1996). Development 122, 983–995.

    PubMed  CAS  Google Scholar 

  32. Slack, J. M. (1995). Development 121, 1569–1580.

    PubMed  CAS  Google Scholar 

  33. Gu, G., Brown, J. R., and Melton, D. A. (2003). Mech. Dev. 120, 35–43.

    Article  PubMed  CAS  Google Scholar 

  34. Sharma, A., Zangen, D. H., Reitz, P., et al. (1999). Diabetes 48, 507–513.

    Article  PubMed  CAS  Google Scholar 

  35. Kritzik, M. R., Jones, E., Chen, Z., et al. (1999). J. Endocrinol. 163, 523–530.

    Article  PubMed  CAS  Google Scholar 

  36. Yamada, S., Kojima, H., Fujimiya, M., Nakamura, T., Kashiwagi, A., and Kikkawa, R. (2001). Am. J. Physiol. Gastrointest. Liver Physiol. 281(1), G229–236.

    PubMed  CAS  Google Scholar 

  37. Kahan, B. W., Jacobson, L. M., Hullett, D. A., et al. (2003). Diabetes 52, 2016–2024.

    Article  PubMed  CAS  Google Scholar 

  38. Schonhoff, S., Baggio, L., Ratineau, C., et al. (2005). Mol. Cell. Biol. 25, 4189–4199.

    Article  PubMed  CAS  Google Scholar 

  39. Suarez-Pinzon, W. L., Lakey, J. R., Brand, S. J., and Rabinovitch, A. (2005). J. Clin. Endocrinol. Metab. 90, 3401–3409.

    Article  PubMed  CAS  Google Scholar 

  40. Lee, H. M., Udupi, V., Englander, E. W., Rajaraman, S., Coffey, R. J. Jr., and Greeley, G. H. Jr. (1999). Endocrinology 140, 4065–4069.

    Article  PubMed  CAS  Google Scholar 

  41. Gomez, G., Udupi, V., Qi, X., Lluis, F., Rajaraman, S., Thompson, J. C., and Greeley, G. H. Jr. (1996). Am. J. Physiol. 271 (3 Pt 1), E582–586.

    PubMed  CAS  Google Scholar 

  42. Ahmad, T., Farnie, G., Bundred, N. J., and Anderson, N. G. (2004). J. Biol. Chem. 279, 1713–1719.

    Article  PubMed  CAS  Google Scholar 

  43. Kuribayashi, A., Kataoka, K., Kurabayashi, T., and Miura, M. (2004). Endocrinology 145, 4976–4984.

    Article  PubMed  CAS  Google Scholar 

  44. Leiter, E. H., Malinski, F. J., and Eppig, J. J. (1978). Cancer Res. 38, 969–977.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Immunology, The Scripps Research Institute, IMM23, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Guoxun Liu, Sandrine Arnaud-Dabernat, Marcie R. Kritzik, You-Qing Zhang & Nora Sarvetnick

  2. Laboratoire de la Biologie de la Differenciation et du Developpement, University Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076, Bordeaux cedex, France

    Sandrine Arnaud-Dabernat

  3. The Islet Research Laboratory, Whittier Institute for Diabetes, Department of Pediatrics, School of Medicine, University of California, 9894 Genesee Ave, San Diego, 92037, La Jolla, USA

    Ayse G. Kayali

Authors
  1. Guoxun Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sandrine Arnaud-Dabernat
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marcie R. Kritzik
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ayse G. Kayali
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. You-Qing Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Nora Sarvetnick
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nora Sarvetnick.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liu, G., Arnaud-Dabernat, S., Kritzik, M.R. et al. PYY in the expanding pancreatic epithelium. Endocr 30, 103–112 (2006). https://doi.org/10.1385/ENDO:30:1:103

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1385/ENDO:30:1:103

Key Words

Search

Navigation