Abstract
Although surgical extirpation by transsphenoidal microsurgery is a major remedy for pituitary adenomas, adjuvant therapy also plays an important role in achieving tumor growth control and endocrine normalization in hormone-secreting tumors. Historically, the treatment options for pituitary adenomas included microsurgery, medical management, and fractionated radiotherapy, but radiosurgery has recently emerged as a practical treatment option. In this paper, we will describe the indications, radiosurgical procedure, results, histological change, and complications of gamma knife radiosurgery (GKS) for pituitary adenomas based on our experience since 1991 and a review of the literature.
Similar content being viewed by others
References
Turner, H. E., Stratton, I. M., Byrne, J. V., Adams, C. B. T., and Wass, J. A. H. (1999). Clin. Endocrinol. 51, 281–284.
Landolt, A. M., Haller, D., Lomax, N., et al. (1998). J. Neurosurg. 88, 1002–1008.
McCord, M. W., Buatti, J. M., Fennell, E. M., et al. (1997). Int. J. Radiat. Oncol. Biol. Phys. 39, 437–444.
Tsang, R. W., Brierley, J. D., Panzarella, T., Gospodarowicz, M. K., Sutcliffe, S. B., and Simpson, W. J. (1994). Int. J. Radiat. Oncol. Biol. Phys. 30, 557–565.
Brada, M., Rajan, B., Traish, D., et al. (1993). Clin. Endocrinol. (Oxf.) 38, 571–578.
Leksell, L. (1968). Acta Chir. Scand. 134, 585–595.
Flickinger, J. C., Lunsford, L. D., Wu, A., and Kalend, A. (1991). Acta Oncol. 30, 363–367.
Leber, K. A., Berglöff, J., and Pendi, G. (1998). J. Neurosurg. 88, 43–50.
Ganz, J. C., Backlund, E.-O., and Thorsen, F. A. (1993). Stereotact. Funct. Neurosurg. 61(Suppl. 1), 30–37.
Ganz, J. C. (1995). Stereotact. Funct. Neurosurg. 64(Suppl. 1), 3–10.
Pollock, B. E., Nippoldt, T. B., Stafford, S. L., Foote, R. L., and Abboud, C. F. (2002). J. Neurosurg. 97, 252–530.
Stephanian, E., Lunsford, L. D., Coffey, R. J., Bissonette, D. J., and Flickinger, J. C. (1992). Neurosurg. Clin. N. Am. 3, 207–218.
Pollock, B. E., Kondziolka, D., Lunsford, L. D., and Flickinger, J. C. (1994). Acta Neurochir. 62(Suppl.), 33–38.
Lim, Y. J., Leem, W., Kim, T. S., Rhee, B. A., and Kim, G. K. (1998). Stereotact. Funct. Neurosurg. 70(Suppl. 1), 95–109.
Martinez, R., Bravo, G., Burzaco, J., and Rey, G. (1998). Stereotact. Funct. Neurosurg. 70(Suppl. 1), 110–118.
Morky, M., Ramschak-Schwarzer, S., Simbrunner, J., Ganz, J. C., and Pendl, G. (1999). Stereotact. Funct. Neurosurg. 72(Suppl. 1), 88–100.
Kim, S. H., Huh, R., Chang, J. W., Park, Y. G., and Chung, S. S. (1999). Stereotact. Funct. Neurosurg. 72(Suppl. 1), 101–110.
Hayashi, M., Izawa, M., Hiyama, H., et al. (1999). Stereotact. Funct. Neurosurg. 72(Suppl. 1), 111–118.
Inoue, H. K., Kohga, H., Hirato, M., et al. (1999). Stereotact. Funct. Neurosurg. 72(Suppl. 1), 125–131.
Wowra, B. and Stummer, W. (2002). J. Neurosurg. 97(Suppl. 5), 429–432.
Losa, M., Valle, M., Mortini, P., et al. (2004). J. Neurosurg. 100, 438–444.
Thorén, M., Rähn, T., Guo, W.-Y., and Werner, S. (1991). Neurosurgery 29, 663–668.
Pan, L., Zhang, N., Wang, E., Wang, B., and Xu, W. (1998). Stereotact. Funct. Neurosurg. 70(Suppl. 1), 119–126.
Morange-Ramos, I., Régis, J., Dufour, H., Andrieu, J. M., Jaquet, P., and Peragut, J. C. (1998). Acta Neurochir. 140, 437–443.
Ikeda, H., Jokura, H., and Yoshimoto, T. (1998). Radiat. Oncol. Invest. 6, 26–34.
Laws, E. R. Jr. and Vance, M. L. (1999). Neurosurg. Clin. N. Am. 10, 327–336.
Landolt, A. M., Haller, D., Lomax, N., et al. (2000). J. Clin. Endocrinol. Metab. 85, 1287–1289.
Ikeda, H., Jokura, H., and Yoshimoto, T. (2001). J. Neurosurg. 95, 285–291.
Seo, Y. and Fukuoka, S. (1995). Surg. Neurol. 43, 170–175.
Landolt, A. M., Lomaz, N., and Scheib, S. G. (2000). In: Contemporary stereotactic radiosurgery: technique and evaluation. Pollock, B. E. (ed.). Futura Publishing Company: New York.
Kobayashi, T., Kida, Y., and Mori, Y. (2002). J. Neurosurg. 97(Suppl. 5), 422–428.
Höybye, C., Grenbäck, E., Rähn, T., Degerblad, M., Thorén, M., and Hulting, A.-L. (2001). Neurosurgery 49, 284–292.
Landolt, A. M. and Lomax, N. (2000). J. Neurosurg. 93(Suppl. 3), 14–18.
Pollock, B. E., Nippoldt, T. B., Stafford, S. T., Foote, R. L., and Abboud, C. F. (2002). J. Neurosurg. 97, 525–530.
Fukuoka, S., Oka, K., Seo, Y., et al. (1998). Stereotact. Funct. Neurosurg. 70, 88–94.
Slattery, W. H. and Brackmann, D. E. (1995). Am. J. Otol. 16, 315–321.
Adams, R. D. (1991). Stereotact. Funct. Neurosurg. 57, 82–86.
Thompson, B. G., Coffey, R. J., Flickinger, J. C., and Lunsford, L. D. (1990). Surg. Neurol. 33, 96–104.
Yamada, S., Vidal, S., Sano, T., Horvath, E., and Kovacs, K. (2003). Pituitary 6, 53–58.
Kamiryo, T., Lopes, M. B. S., Kassell, N. F., Steiner, L., and Lee, K. S. (2001). Neurosurgery 49, 409–415.
Yang, T., Wu, S. L., Liang, J. C., Rao, Z. R., and Ju, G. (2000). Neurosurgery 47, 407–415.
Blatt, D. R., Friedman, W. A., Bova, F. J., Theele, D. P., and Mickle, J. P. (1994). J. Neurosurg. 80, 1046–1055.
Fajardo, L. F. and Berthrong, M. (1988). Pathol. Annu. 23, 297–330.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Akabane, A., Yamada, S. & Jokura, H. Gamma knife radiosurgery for pituitary adenomas. Endocr 28, 87–91 (2005). https://doi.org/10.1385/ENDO:28:1:087
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1385/ENDO:28:1:087