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Pituitary tumors

Prognostic indicators

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Abstract

Many factors influence the proliferation of pituitary adenomas: angiogenesis, apoptosis, growth factors, oncogenes, tumor suppressor genes, and hormone receptors. These elements can be demonstrated by immunohistochemistry and/or molecular pathology but no single factor can be used for determination of biological behavior resp. prognosis. Pituitary adenomas can be enclosed or invasive and may be very large or may be microadenomas, but the most important point for prognosis is the total resection in the first or second surgery or the reaction on treatments by drugs. Especially for residual tumor tissue proliferation, markers are important because they may indicate the growth rate and the aggressiveness of the tumor. Radiation therapy is indicated in many of these recurrent tumors and can improve the prognosis.

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References

  1. Lloyd, R. J., Kovacs, K., Young, W. F. Jr., et al. (2004). In: Pathology and genetics. Tumours of endocrine tumours. DeLellis, R. A., Lloyd, R. V., and Heitz, P. U. (eds.). IARC: Lyon, pp. 9–48.

    Google Scholar 

  2. Sautner, D. and Saeger, W. (1991). Path. Res. Pract. 187, 632–636.

    PubMed  CAS  Google Scholar 

  3. Saeger, W., Lüdecke, B., and Lüdecke, D. K. (2004). Endocr. Pathol. 15, 264–265.

    Google Scholar 

  4. Pizarro, C. B., Oliveira, M. C., Coutinho, L. B., and Ferreira, N. P. (2004). Braz. J. Med. Biol. Res. 37, 235–243.

    Article  PubMed  CAS  Google Scholar 

  5. Buckley, N., Bates, A. S., Broome, J. C., et al. (1994). J. Clin. Endocrinol. Metab. 79, 1513–1516.

    Article  PubMed  CAS  Google Scholar 

  6. Oliveira, M. C., Marroni, C. P., Pizarro, C. B., Pereira-Lima, J. F., Barbosa-Coutinho, L. M., and Ferreira, N. P. (2002). Braz. J. Med. Biol. Res. 35, 561–565.

    PubMed  CAS  Google Scholar 

  7. Meij, B. P., Lopes, M. B. S., Ellegala, D. B., Alden, T. D., and Laws, E. R. (2002). J. Neurosurg. 96, 195–208.

    PubMed  Google Scholar 

  8. Ezzat, S., Kontogeorgos, G., Redelmeier, D. A., Horvath, E., Harris, A. G., and Kovacs, K. (1995). Eur. J. Endocrinol. 133, 686–690.

    PubMed  CAS  Google Scholar 

  9. Asa, S. L., Kovacs, K., Horvath, E., Singer, W., and Smyth, H. S. (1992). J. Clin. Endocrinol. Metab. 13, 79–87.

    Google Scholar 

  10. Asa, S. L. (1998). Tumors of the pituitary gland. Armed Forces Institute of Pathology: Washington, DC.

    Google Scholar 

  11. Schreiber, S., Saeger, W., and Lüdecke, D. K. (1999). Pituitary 1, 213–220.

    Article  PubMed  CAS  Google Scholar 

  12. Saeger, W. (1995). Endocr. Pathol. 6, 379–380.

    Google Scholar 

  13. Machiavelli, G. A., Rivolta, C. M., Artese, R., Basso, A., and Burdman, J. A. (1998). Neurol. Res. 20, 709–712.

    PubMed  CAS  Google Scholar 

  14. Auer, L. M. and Clarici, G. (1985). Neurol. Res. 7, 153–160.

    PubMed  CAS  Google Scholar 

  15. Turner, H. E., Nagy, Z., Gatter, K. C., Esiri, M. M., Harris, A. L., and Wass, J. A. H. (2000). J. Endocrinol. 165, 475–481.

    Article  PubMed  CAS  Google Scholar 

  16. Vidal, S., Horvath, E., Kovacs, K., and Scheithauer, B. W. (2004). In: Endocrine pathology. Differential diagnosis and molecular advances. Lloyd, R. V. (ed.). Humana Press: Totowa, NJ, pp. 61–74.

    Google Scholar 

  17. Landolt, A. M., Shibata, T., and Kleihues, P. (1987). J. Neurosurg. 67, 803–806.

    PubMed  CAS  Google Scholar 

  18. Hsu, D. W., Hakim, F., Biller, B. M., et al. (1993). J. Neurosurg. 78, 753–761.

    PubMed  CAS  Google Scholar 

  19. Nose-Alberti, V., Mesquita, M. I. S., Martin, L. C., and Kayath, M. J. (1998). Endocr. Pathol. 9, 53–62.

    PubMed  CAS  Google Scholar 

  20. Espay, A. J., Azzarelli, B., Williams, L. S., and Bodensteiner, J. B. (2001). J. Child. Neurol. 16, 364–367.

    PubMed  CAS  Google Scholar 

  21. Hentschel, S. J., McCutcheon, I. E., Moore, W., and Durity, F. A. (2003). Can. J. Neurol. Sci. 30, 215–219.

    PubMed  Google Scholar 

  22. Vidal, S., Kovacs, K., Horvath, E., et al. (2002). Mod. Pathol. 15, 1205–1212.

    Article  PubMed  Google Scholar 

  23. Münscher, A., Schmid, M., Saeger, W., Schreiber, S., and Lüdecke, D. K. (2001). Endocr. Pathol. 12, 171–180.

    Article  PubMed  Google Scholar 

  24. Lloyd, R. V., Jin, L., Qian, X., and Kulig, E. (1997). Am. J. Pathol. 150, 401–407.

    PubMed  CAS  Google Scholar 

  25. Korbonits, M., Chahal, H. S., Kaltsas, G., et al. (2002). J. Clin. Endocrinol. Metab. 87, 2635–2643.

    Article  PubMed  CAS  Google Scholar 

  26. Bamberger, C. M., Fehn, M., Bamberger, A. M., et al. (1999). Eur. J. Endocrinol. 140, 250–255.

    Article  PubMed  CAS  Google Scholar 

  27. Nakabayashi, H., Sunada, I., and Hara, M. (2001). J. Histochem. Cytochem. 49, 1193–1194.

    PubMed  CAS  Google Scholar 

  28. Liu, W., Asa, S. L., and Ezzat, S. (2002). Brain Pathol. 12, 412–419.

    Article  PubMed  CAS  Google Scholar 

  29. Kontogeorgos, G., Kovacs, K., and Scheithauer, B. W. (1994). Endocr. Pathol. 5, 1–3.

    Article  Google Scholar 

  30. Saeger, W. (2000). Endocr. Pathol. 11, 295–300.

    Article  PubMed  CAS  Google Scholar 

  31. Renner, U., Paez-Pereda, M., Arzt, E., and Stalla, G. K. (2004). In: Molecular pathology of the pituitary. Kontogeorgos, G. and Kovacs, K. (eds.). Karger: Basel, p. 109.

    Google Scholar 

  32. Renner, U., Lohrer, P., Schaaf, L., et al. (2000). Endocrinology 143, 3759–3765.

    Article  CAS  Google Scholar 

  33. Kontogeorgos, G., Stefaneanu, L., Kovacs, K., and Cheng, Z. (1996). Endocr. Pathol. 7, 63–70.

    PubMed  CAS  Google Scholar 

  34. Le Riche, V. K., Asa, S. L., and Ezzat, S. (1996). J. Clin. Endocrinol. Metab. 81, 656–662.

    Article  Google Scholar 

  35. Heaney, A. P., Horwitz, G. A., Wang, Z. Y., Singson, R., and Melmed, S. (1999). Nat. Med. 5, 1317–1321.

    Article  PubMed  CAS  Google Scholar 

  36. Missale, C. and Spano, P. (1998). Front. Neuroendocrinol. 19, 128–150.

    Article  PubMed  CAS  Google Scholar 

  37. Green, V. L., White, M. C., Hipkin, L. J., Jeffreys, R. V., Foy, P. M., and Atkin, S. L. (1997). Eur. J. Endocrinol. 136, 382–387.

    PubMed  CAS  Google Scholar 

  38. Kulig, E., Jin, L., Qian, X., et al. (1999). Am. J. Pathol. 154, 767–774.

    PubMed  CAS  Google Scholar 

  39. Gaffey, T. A., Scheithauer, B. W., Leech, R. W., et al. (2005). Clin. Neuropathol. 24, 56–63.

    PubMed  Google Scholar 

  40. Ezzat, S., Zheng, L., Smyth, H. S., and Asa, S. L. (1997). Clin. Endocrinol. (Oxf.) 46, 599–606.

    Article  CAS  Google Scholar 

  41. Yu, R. and Melmed, S. (2001). Brain Pathol. 11, 328–341.

    Article  PubMed  CAS  Google Scholar 

  42. Jordan, S., Lidhar, K., Korbonits, M., Lowe, D. G., and Grossman, A. B. (2000). Eur. J. Endocrinol. 143, R1-R6.

    Article  PubMed  CAS  Google Scholar 

  43. Turner, H. E., Nagy, Z., Sullivan, N., Esiri, M. M., and Wass, J. A. H. (2000). Clin. Endocrinol. 53, 337–344.

    Article  CAS  Google Scholar 

  44. Saeger, W., Schreiber, S., and Lüdecke, D. K. (2001). Endocr. Pathol. 12, 39–47.

    Article  PubMed  CAS  Google Scholar 

  45. Barlier, A., Gunz, G., Zamora, A. J., et al. (1998). J. Clin. Endocrinol. Metab. 83, 1604–1610.

    Article  PubMed  CAS  Google Scholar 

  46. Musat, M., Vax, V. V., Borboli, N., et al. (2004). In: Molecular pathology of the pituitary. Konto-georgos, G. and Kovacs, K. (eds.). Karger: Basal, pp. 34–62.

    Chapter  Google Scholar 

  47. Zhuang, Z. P., Ezzat, S. Z., Vortmeyer, A. O., et al. (1997). Cancer Res. 57, 5446–5451.

    PubMed  CAS  Google Scholar 

  48. Asa, S. L., Somers, K., and Ezzat, S. (1998). J. Clin. Endocrinol. Metab. 83, 3210–3212.

    Article  PubMed  CAS  Google Scholar 

  49. Pei, L., Melmed, S., Scheithauer, B. W., Kovacs, K., Benedict, W. F., and Prager, D. (1995). Cancer Res. 55, 1613–1616.

    PubMed  CAS  Google Scholar 

  50. Simpson, D. J., Magnay, J., Bicknell, J. E., et al. (1999). Cancer Res. 59, 1562–1566.

    PubMed  CAS  Google Scholar 

  51. Levy, A., Hall, L., Yeudall, W. A., and Lightman, S. L. (1994). Clin. Endocrinol. 41, 809–814.

    CAS  Google Scholar 

  52. Pagotto, U., Arzberger, T., Theodoropoulou, M., et al. (2000). Cancer Res. 60, 6794–6799.

    PubMed  CAS  Google Scholar 

  53. Zhang, X., Sun, H. P., Danila, D. C., et al. (2002). J. Clin. Endocrinol. Metab. 87, 1262–1267.

    Article  PubMed  CAS  Google Scholar 

  54. Farrell, W. E. and Clayton, R. N. (2000). Front. Neuroendocrinol. 21, 174–198.

    Article  PubMed  CAS  Google Scholar 

  55. Heaney, A. P. and Melmed, S. (2000). Endocr. Relat. Cancer 7, 3–15.

    Article  PubMed  CAS  Google Scholar 

  56. Simpson, D. J., Bicknell, J. E., McNicol, A. M., Clayton, R. N., and Farrell, W. E. (1999). Genes Chromosomes Cancer 24, 328–336.

    Article  PubMed  CAS  Google Scholar 

  57. Woloschak, M., Yu, A. Q., and Post, K. D. (1997). Mol. Carcinogen. 19, 221–224.

    Article  CAS  Google Scholar 

  58. Woloschak, M., Yu, A. Q., Xiao, J. Q., and Post, K. D. (1996). Cancer Res. 56, 2493–2496.

    PubMed  CAS  Google Scholar 

  59. Lloyd, R. V., Erickson, L. A., Jin, L., et al. (1999). Am. J. Pathol. 154, 313–323.

    PubMed  CAS  Google Scholar 

  60. Mizutani, T., Teramoto, A., Aruga, T., et al. (1993). Neurosurgery 33, 907–910.

    Article  PubMed  CAS  Google Scholar 

  61. Abe, T. and Lüdecke, D. K. (2001). Eur. J. Endocrinol. 145, 137–145.

    Article  PubMed  CAS  Google Scholar 

  62. Hardy, J. (1973). In: Diagnosis and treatment of pituitary tumors. Kohler, P. O. and Ross, G. T. (eds.). Excerpta Medica: Amsterdam, pp. 179–194.

    Google Scholar 

  63. Kizilkilic, O., Yalcin, O., Yildirim, T., Sener, L., Parmaksiz, G., and Erdogan, B. (2005). Am. J. Neuroradiol. 26, 65–67.

    PubMed  Google Scholar 

  64. Radner, H., Katenkamp, D., Reifenberger, G., Deckert, M., Pietsch, T., and Wiestler, O. D. (2001). Virchows Arch. 438, 321–335.

    Article  PubMed  CAS  Google Scholar 

  65. Rees, D. A., Hanna, F. W. F., Davies, J. S., Mills, R. G., Vafidis, J., and Scanlon, M. F. (2002). Clin. Endocrinol. 56, 541–551.

    Article  CAS  Google Scholar 

  66. Molitch, M. E. (2002). Pituitary 5, 55–65.

    Article  PubMed  CAS  Google Scholar 

  67. Bevan, J. S., Webster, J., Burke, C. W., and Scanlon, M. F. (1992). Endocr. Rev. 13, 220–240.

    Article  PubMed  CAS  Google Scholar 

  68. Saeger, W. (1992). Microsc. Res. Techn. 20, 162–176.

    Article  CAS  Google Scholar 

  69. Hamester, U., Saeger, W., and Lüdecke, D. K. (1987). Histol. Histopathol. 2, 135–142.

    PubMed  CAS  Google Scholar 

  70. Freda, P. U. (2002). J. Clin. Endocrinol. Metab. 87, 3013–3018.

    Article  PubMed  CAS  Google Scholar 

  71. Barkan, A. L., Kelch, R. P., Hopwood, N. J., and Beitins, I. Z. (1988). J. Clin. Endocrinol. Metab. 66, 16–23.

    Article  PubMed  CAS  Google Scholar 

  72. Beck-Peccoz, P., Brucker-Davis, F., Persani, L., Smallridge, R. C., and Weintraub, B. D. (1996). Endocr. Rev. 17, 610–638.

    Article  PubMed  CAS  Google Scholar 

  73. Molitch, M. E. (2001). In: Diagnosis and management pituitary tumors. Thapar, K., Kovacs, K., Scheithauer, B. W., and Lloyd, R. V. (eds.). Humana Press: Totowa, NJ, pp. 247–268.

    Google Scholar 

  74. Petersenn, S., Lüdecke, D. K., Fahlbusch, R., et al. (2005). Dtsch. Ärztebl., in press.

  75. Kovalic, J. J., Grigsby, P. W., and Fineberg, B. B. (1990). Radiology 177, 273–275.

    PubMed  CAS  Google Scholar 

  76. Milker-Zabel, S., Zabel, A., Huber, P., Schlegel, W., Wannenmacher, M., and Debus, J. (2004). Int. J. Radiat. Oncol. Biol. Phys. 59, 1088–1096.

    Article  PubMed  Google Scholar 

  77. Engenhart-Cabillic, R., Kocher, M., Muller, R. P., et al. (1999). Deut. Med. Wochenschr. 124, 1148–1152.

    CAS  Google Scholar 

  78. Wowra, B. and Stummer, W. (2002). J. Neurosurg. 97, 429–432.

    PubMed  Google Scholar 

  79. Landolt, A. M., Haller, D., Lomax, N., et al. (1998). J. Neurosurg. 88, 1002–1008.

    PubMed  CAS  Google Scholar 

  80. Minniti, G., Jaffrain-Rea, M. L., Osti, M., et al. (2005). Clin. Endocrinol. 62, 210–216.

    Article  Google Scholar 

  81. Ruebel, K., Jin, L., Qian, X., et al. (2005). Cancer Res. 65, 1136–1140.

    Article  PubMed  CAS  Google Scholar 

  82. Gerlach, H. and Jänisch, W. (1979). Zentralbl. Neurochir. 40, 131–136.

    PubMed  CAS  Google Scholar 

  83. Yamamoto, A., Hashimoto, N., Yamashita, J., and Kikuchi, H. (1989). Neurol. Surg. 17, 193–196.

    CAS  Google Scholar 

  84. Powell, H. C., Marshall, L. F., and Ignelzi, R. J. (1977). Acta Neuropath. (Berlin) 39, 165–167.

    Article  CAS  Google Scholar 

  85. Flitsch, J., Lüdecke, D. K., Saeger, W., and Westphal, M. (2005). Exper. Clin. Endocrinol. Diabetes 113, S67 (Abstr. Nr. 158).

  86. Lübke, D. and Saeger, W. (1995). Gener. Diagn. Pathol. 141, 81–92.

    Google Scholar 

  87. Gaffey, T. A., Scheithauer, B. W., Lloyd, R. V., et al. (2002). J. Neurosurg. 96, 352–360.

    Article  PubMed  Google Scholar 

  88. Cai, W. Y., Alexander, J. M., Hedley-Whyte, E. T., et al. (1994). J. Clin. Endocrinol. Metab. 78, 89–93.

    Article  PubMed  CAS  Google Scholar 

  89. Landman, R. E., Horwith, M., Peterson, R. E., Khandji, A. G., and Wardlaw, S. L. (2002). J. Clin. Endocrinol. Metab. 87, 3084–3089.

    Article  PubMed  CAS  Google Scholar 

  90. Scheithauer, B. W. (2004). In: Sternberg’s diagnostic surgical pathology. Mills, S. E., Carter, D., Greenson, J. K., et al. (eds.). Lippincott, Williams and Wilkens: Philadelphia, pp. 521–556.

    Google Scholar 

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  1. Institute of Pathology of the Marienkrankenhaus Hamburg, University of Hamburg, Hamburg, Germany

    Wolfgang Saeger

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Saeger, W. Pituitary tumors. Endocr 28, 57–66 (2005). https://doi.org/10.1385/ENDO:28:1:057

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